CARD15 gene mutations in periodontitis

Journal of Clinical Periodontology
M L LaineA J van Winkelhoff

Abstract

The CARD15 gene encodes the Nod2 protein, which is involved in intracellular recognition of bacterial products like peptidoglycan, activates inflammation and regulates apoptosis through nuclear factor-kappa B, a transcription factor that plays a central role in the innate immunity. Two functional mutations, an insertion mutation at nucleotide 3020 (3020insC) and a missense mutation C2104T in the CARD15 gene (originally NOD2 gene) have been reported to be associated with Crohn's disease. Our aim was to investigate the occurrence of CARD15 gene polymorphisms in adult patients with periodontitis taking into account smoking and presence of putative periodontal pathogens as additional variables. A case-control study was performed in 104 Dutch Caucasian patients with severe adult periodontitis (54 non-smokers and 50 smokers, mean age 46 years) and in 97 ethnically matched, periodontal healthy controls (73 non-smokers and 24 smokers, mean age 40 years). DNA isolated from a mouthwash was typed with PCR technology. Presence of putative periodontal pathogens was established by culture technique. Frequencies of the CARD15 3020insC and 2104T mutations were similar in the periodontitis group and in the control group (5.1% and 13.3%; 5.2% an...Continue Reading

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Citations

Jan 9, 2007·Inflammatory Bowel Diseases·Liesbet Henckaerts, Séverine Vermeire
Mar 27, 2010·International Journal of Dentistry·Marja L LaineW Crielaard
Sep 2, 2005·Periodontology 2000·Denis F KinaneThomas C Hart
Sep 1, 2005·Journal of Clinical Periodontology·Bruno G LoosMarja L Laine
Jan 12, 2007·Periodontology 2000·Hiromasa YoshieJohnah C Galicia
Sep 13, 2006·Journal of Clinical Periodontology·B NoackH K Schackert
Dec 3, 2011·Periodontology 2000·Marja L LaineBruno G Loos
Sep 18, 2013·The Science of the Total Environment·Robert JandlFranco Miglietta
Oct 26, 2005·Journal of Dental Research·M L LaineA S Peña
Mar 9, 2006·Clinical and Vaccine Immunology : CVI·Chantal A A van der GraafBart Jan Kullberg
Sep 23, 2006·Scandinavian Journal of Gastroenterology·Carles de DiegoPedro Martínez-Castro
Dec 29, 2020·Acta Odontologica Scandinavica·Alejandro I Lorenzo-PousoPablo Vega
Dec 19, 2017·American Journal of Obstetrics and Gynecology·Jerome F StraussHarvey A Schenkein

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