CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Ying ChenWenshan Lv

Abstract

BACKGROUND &AIM: Previous studies have suggested genetic factors are involved in the development of gout. We performed a case-control study to investigate the genetic association between CARD8 rs2043211 polymorphism and gout. A total of 396 male patients with gout and 403 age- and sex- matched healthy controls were included in this study. Genotyping was performed using TaqMan SNP Genotyping Assays. An association analysis was carried out using the χ² test. The genotype-phenotype analysis was also conducted. The genotype distribution of CARD8 rs2043211 polymorphism confirmed to HWE in the controls (P = 0.27). There was an obvious difference in the genotype distribution of CARD8 rs2043211 polymorphism between cases and controls (P = 0.017). In addition, there was an obvious association between CARD8 rs2043211 polymorphism and gout under the recessive comparison model (AA vs. OR = 0.65, 95%CI 0.47-0.88, P = 0.006). Patients carrying genotype TT of CARD8 rs2043211 polymorphism had higher triglycerides levels compared to those carrying the AA genotype (2.77±2.08 mmol/L vs. 2.07±1.15 mmol/L, P = 0.01). Patients with the TT genotype also had significantly higher systolic blood pressure compared with those with the AA genotype (142.11±...Continue Reading

Citations

Oct 16, 2015·Arthritis Research & Therapy·Cushla McKinneyTony R Merriman
Dec 17, 2017·Annals of the Rheumatic Diseases·Anna L GoslingTony R Merriman
Dec 24, 2018·Current Opinion in Rheumatology·Vicky TaiNicola Dalbeth
May 10, 2018·Nature Reviews. Rheumatology·Tanya J MajorTony R Merriman
Oct 18, 2020·Environmental Science and Pollution Research International·Long MiaoYuepu Pu
May 1, 2021·Journal of Clinical Medicine·Paola GalozziPaolo Sfriso
Jun 1, 2021·Expert Review of Clinical Immunology·Paola GalozziFrancesca Oliviero
Aug 15, 2021·International Journal of Rheumatic Diseases·Denise Clavijo-CornejoMarwin Gutierrez

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