PMID: 8951908Oct 1, 1996Paper

Cardiac 123I-MIBG uptake is affected by variable uptake in reference regions: implications for interpretation in clinical studies

Nuclear Medicine Communications
G A SomsenE A van Royen

Abstract

Cardiac 123I-meta-iodobenzyl guanidine (123I-MIBG) uptake, using the mediastinal region as a reference, is a predictor of outcome in heart failure. Constant uptake in a reference region is required when studying the pharmacotherapeutic effects on the integrity of the cardiac adrenergic system. The aim of this study was to verify the assumption of constant uptake in reference regions and their relation to established predictors of clinical outcome. Planar 123I-MIBG images were obtained in 28 patients with heart failure. The left ventricular ejection fraction correlated with the heart-to-mediastinum (H/M) ratio but not with myocardial 123I-MIBG uptake. Plasma noradrenaline correlated with the H/M ratio, the heart-to-lung (H/L) ratio, mediastinal uptake and age, but not with uptake in the myocardium and lung. Age correlated with the H/M ratio, H/L ratio, mediastinal uptake and lung uptake, but not with myocardial uptake. In a regression model, after the inclusion of age, the H/M ratio and mediastinal uptake were not related to noradrenaline. We conclude that changes in the H/M and H/L ratios are predominantly due to confounding changes in mediastinal uptake or lung uptake. In pharmacological intervention studies, myocardial 123I-M...Continue Reading

Citations

Nov 8, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Denis AgostiniHein J Verberne
Jan 30, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Arnold F Jacobson, Dale T Matsuoka
Mar 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G Aernout SomsenAlberto Righetti
Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wengen ChenHongming Zhuang
Mar 5, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Hein J VerberneArnold F Jacobson
Oct 9, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Hein J VerberneArnold F Jacobson

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