Cardiac β3 -adrenoceptors-A role in human pathophysiology?

British Journal of Pharmacology
Ebru Arioglu-InanMartin C Michel

Abstract

As β3 -adrenoceptors were first demonstrated to be expressed in adipose tissue they have received much attention for their metabolic effects in obesity and diabetes. After the existence of this subtype had been suggested to be present in the heart, studies focused on its role in cardiac function. While the presence and functional role of β3 -adrenoceptors in the heart has not uniformly been detected, there is a broad consensus that they become up-regulated in pathological conditions associated with increased sympathetic activity such as heart failure and diabetes. When detected, the β3 -adrenceptor has been demonstrated to mediate negative inotropic effects in an inhibitory G protein-dependent manner through the NO-cGMP-PKG signalling pathway. Whether these negative inotropic effects provide protection from the adverse effects induced by overstimulation of β1 /β2 -adrenoceptors or in themselves are potentially harmful is controversial, but ongoing clinical studies in patients with congestive heart failure are testing the hypothesis that β3 -adrenceptor agonism has a beneficial effect. LINKED ARTICLES: This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section ...Continue Reading

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Citations

Dec 20, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Massimo Dal MonteMartin C Michel
Apr 19, 2019·Cells·Giorgia Schena, Michael J Caplan
Jun 27, 2019·British Journal of Pharmacology·Martin C MichelRoger J Summers
Dec 2, 2020·Cells·Betul R ErdoganEbru Arioglu-Inan
Dec 6, 2020·Cells·Lauriane Y M MichelJean-Luc Balligand
Jan 29, 2021·British Journal of Pharmacology·Samantha L SaundersTimothy V Murphy
Nov 21, 2020·Journal of Medicinal Chemistry·Gang XingMao-Sheng Cheng

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