Cardiac adaptation in asphyxiated infants treated with therapeutic hypothermia

Journal of Neonatal-perinatal Medicine
Arvind SehgalC Huynh

Abstract

Hypoxic ischemic encephalopathy (HIE) affects  one to two newborns per 1,000 live births and oftentimes involves multi-organ insult. The objectives were to assess the evolution of cardiac function in infants with HIE treated with therapeutic hypothermia using echocardiography (ECHO). Archived data during the period 2010-2016 was assessed. Amongst the infants with baseline ECHO assessments, a sub-cohort which had assessments in all the three phases (baseline/pre-active cooling [T1], cooling [T2] and rewarming [T3]) was analyzed separately. Thirty three infants formed part of the overall cohort, the gestation and birthweight were 39.6 ± 1.6 weeks and 3306 ± 583 g, respectively. Baseline (T1) information noted impaired cardiac performance (right ventricle stroke volume 1.08 ± 0.04 ml/kg, fractional area change [FAC] 24 ± 0.5% and tricuspid annular peak systolic excursion [TAPSE] 7.46 ± 0.11mm). Serial information was available for 24 of 33 infants. Cardiac function improved significantly between the cooling and the re-warming kphases. This included changes in right ventricular output (127 ± 34 vs 164 ± 47 ml/kg/min, p <0.01) and FAC (20 ± 3 vs 28 ± 2%, p<0.01). Pairwise comparisons for fractional shortening did not show significan...Continue Reading

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Citations

Oct 31, 2019·British Journal of Clinical Pharmacology·Laurent M A FaviéUNKNOWN PharmaCool study group*
Mar 17, 2020·Frontiers in Pediatrics·Mihaela Roxana PopescuAna-Maria Zagrean
May 12, 2020·The Journal of Pediatrics·Arvind SehgalSamuel Menahem
Feb 25, 2021·Pediatrics·Arvind SehgalStuart B Hooper

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