Cardiac aging and heart disease in humans

Biophysics Reviews
Marja Steenman, Gilles Lande

Abstract

The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing age. In order to improve patient care and prevention for age-related cardiac diseases, insight should be gained from the analysis of processes involved in and leading to cardiac aging. It is from this perspective that we provide here an overview of changes associated with age in the heart on four levels: functional, structural, cellular and molecular. We highlight those changes that are in common with the development of the two major age-associated cardiac pathologies: heart failure and atrial fibrillation. These commonly affected processes in aging and cardiac pathophysiology may provide an explanation for the age risk factor in cardiac disease.

References

Dec 1, 1987·The Journal of Pathology·I Steiner
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Sep 4, 1999·Circulation Research·D R Van WagonerJ M Nerbonne
Sep 14, 1999·Journal of the American Geriatrics Society·G Gregoratos
Jun 8, 2001·Mechanisms of Ageing and Development·C R Gazoti DebessaR Rodrigues de Souza
Jun 21, 2001·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·C M ChungM T Walsh
Jul 4, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Edward G Lakatta, Steven J Sollott
Oct 16, 2002·Circulation·Christoph RöckenAndreas Goette
Nov 5, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thomas Unger, Jun Li
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Sandra A Jones
Jun 30, 2007·Clinical Chemistry·Robert B NeumanSamuel C Dudley
Feb 26, 2008·Journal of the American College of Cardiology·Brett Burstein, Stanley Nattel
Feb 10, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Shahriar Iravanian, Samuel C Dudley
Aug 6, 2010·European Journal of Heart Failure·Carolyn S P LamRamachandran S Vasan
Aug 21, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jun RenJames R Sowers
Aug 9, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bart MaesenUlrich Schotten
Nov 24, 2011·Heart Failure Clinics·James B Strait, Edward G Lakatta
Jan 11, 2012·Antioxidants & Redox Signaling·Dao-Fu DaiPeter S Rabinovitch
Mar 21, 2012·European Journal of Heart Failure·John J V McMurrayHenry Krum
Apr 19, 2012·Circulation Research·Jonathan L RespressXander H T Wehrens
Jun 1, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Rodney H Falk
Nov 13, 2012·Journal of the American College of Cardiology·Liang-Han LingAndrew J Taylor
Jan 11, 2014·Frontiers in Physiology·Nicola FerraraDomenico Bonaduce
May 6, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alfredo Di PinoPaolo Guccione
Jun 22, 2014·Circulation Research·Kavita Sharma, David A Kass
Jun 27, 2014·Clinical Epidemiology·Massimo Zoni-BerissoStefano Domenicucci
Dec 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michele EmdinGiuseppe Vergaro
Dec 4, 2014·Lancet·Eugene Braunwald
Dec 17, 2014·Journal of Molecular and Cellular Cardiology·Hirad A FeridooniSusan E Howlett
Dec 30, 2014·JACC. Heart Failure·Frederik H VerbruggeWilfried Mullens
Mar 19, 2015·The New England Journal of Medicine·Don C RockeyJoseph A Hill
Jul 15, 2015·Scientific Reports·Wenjun XieAndrew R Marks
Jul 21, 2015·Biochimica Et Biophysica Acta·Autumn TocchiPeter S Rabinovitch
Aug 22, 2015·Journal of the American College of Cardiology·Mikhail S DzeshkaEduard Shantsila

❮ Previous
Next ❯

Citations

Jul 29, 2018·Nature Reviews. Cardiology·Natalie A GudeMark A Sussman
Jan 25, 2019·Journal of Cardiovascular Medicine·Georgios GeorgiopoulosKimon Stamatelopoulos
Oct 19, 2019·Pflügers Archiv : European journal of physiology·Saber Ghazizadeh DarbandMaryam Majidinia
Nov 7, 2019·Annual Review of Pathology·Megan A EvansKenneth Walsh
Oct 1, 2018·The European Journal of Neuroscience·Aliza K De Nobrega, Lisa C Lyons
Dec 6, 2019·Briefings in Bioinformatics·Bohdan B KhomtchoukThemistocles L Assimes
Jan 15, 2020·Nature Medicine·Sara AhadiMichael Snyder
May 1, 2019·BMC Public Health·Haleh AyatollahiMasoud Salehi
May 21, 2020·American Journal of Physiology. Cell Physiology·Evan TracyAmanda J LeBlanc
Mar 12, 2019·Aging·Moshi SongGuang-Hui Liu
Sep 3, 2020·Clinical & Translational Immunology·Shiqing ZhangZhaoliang Su
Mar 19, 2019·Frontiers in Physiology·Marie StricklandAnis Larbi
May 17, 2019·International Journal of Molecular Sciences·Shanna Hamilton, Dmitry Terentyev
Apr 29, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Pere AlmagroJesús Recio
Jul 10, 2018·BioMed Research International·James Oluwagbamigbe FajemiroyeGustavo Rodrigues Pedrino
Jan 27, 2019·Aging Cell·Stéphanie ChacarNassim Fares
May 17, 2019·Oxidative Medicine and Cellular Longevity·Danyang Tian, Jinqi Meng
Feb 13, 2020·Pflügers Archiv : European journal of physiology·Mi-Hyun NoHyo-Bum Kwak
Mar 3, 2020·Frontiers in Physiology·K Lockhart JamiesonJohn M Seubert
Dec 8, 2019·Aging Clinical and Experimental Research·Christina PagiatakisRoberto Papait
Sep 11, 2020·GeroScience·Su-Jeong KimKelvin Yen
May 1, 2019·Journal of Cardiovascular Development and Disease·Jennifer L RodgersSiva K Panguluri
Nov 7, 2019·Current Pharmaceutical Design·Andreea CorinaManfredi Rizzo
Aug 7, 2020·American Journal of Physiology. Cell Physiology·Sophie I HamstraVal A Fajardo
May 26, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Şahbender Koç, Sadettin Selçuk Baysal
Nov 1, 2018·Temperature : Multidisciplinary Biomedical Journal·Tiina M Ikäheimo
Apr 3, 2020·Healthcare·Ava NiakoueiLawrence Fulton
Oct 20, 2018·Frontiers in Physiology·Nathan C DenhamKatharine M Dibb
Oct 26, 2018·Circulation Research·Alice E Kane, David A Sinclair
Apr 24, 2020·Frontiers in Human Neuroscience·Cosimo TuenaMarco Stramba-Badiale
Oct 22, 2019·American Journal of Physiology. Renal Physiology·Alfonso Eirin, Lilach O Lerman
Nov 10, 2020·Seminars in Immunopathology·Weili XuAnis Larbi
Jan 1, 2021·Database : the Journal of Biological Databases and Curation·Bohdan B KhomtchoukRobert L Grossman
Jan 13, 2021·Ageing Research Reviews·Yohan SantinJeanne Mialet-Perez
Jan 11, 2020·Computational and Structural Biotechnology Journal·Paula Santos-OtteStuart Maudsley
Dec 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Denise BörzseiAnikó Pósa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

The American Journal of Geriatric Cardiology
Edward G Lakatta
European Journal of Heart Failure
Liza S M WongPim van der Harst
© 2022 Meta ULC. All rights reserved