Cardiac amyloidosis: the great pretender

Heart Failure Reviews
Claudio RapezziMathew S Maurer

Abstract

Cardiac amyloidosis (CA) is often misdiagnosed because of both physician-related and disease-related reasons including: fragmented knowledge among different specialties and subspecialties, shortage of centres and specialists dedicated to disease management, erroneous belief it is an incurable disease, rarity of the condition, intrinsic phenotypic heterogeneity, genotypic heterogeneity in transthyretin-related forms and the necessity of target organ tissue histological diagnosis in the vast majority of cases. Pitfalls, incorrect beliefs and deceits challenge not only the path to the diagnosis of CA but also the precise identification of aetiological subtype. The awareness of this condition is the most important prerequisite for the management of the risk of underdiagnoses and misdiagnosis. Almost all clinical, imaging and laboratory tests can be misinterpreted, but fortunately each of these diagnostic steps can also offer diagnostic "red flags" (i.e. highly suggestive findings that can foster the correct diagnostic suspicion and facilitate early, timely diagnosis). This is especially important because outcomes in CA are largely driven by the severity of cardiac dysfunction and emerging therapies are aimed at preventing further a...Continue Reading

References

Jan 1, 1982·The American Journal of Cardiology·J D CarrollK P McAdam
Feb 13, 1997·The New England Journal of Medicine·D R JacobsonJ N Buxbaum
Jun 7, 2002·The New England Journal of Medicine·Helen J LachmannPhilip N Hawkins
Aug 9, 2003·The New England Journal of Medicine·Giampaolo Merlini, Vittorio Bellotti
Jan 5, 2005·Circulation·Alicia Maria MaceiraDudley John Pennell
Sep 28, 2005·Circulation·Rodney H Falk
Feb 13, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Claudio RapezziAngelo Branzi
Feb 18, 2010·JACC. Cardiovascular Imaging·Imran S SyedMartha Grogan
May 19, 2010·Nature Reviews. Cardiology·Claudio RapezziAngelo Branzi
Nov 12, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Claudio RapezziAngelo Branzi
Sep 29, 2011·The American Journal of Surgical Pathology·Anjali A SatoskarTibor Nadasdy
Jul 14, 2012·JACC. Cardiovascular Imaging·Candida Cristina QuartaClaudio Rapezzi
Dec 1, 2012·Current Medical Research and Opinion·Violaine Planté-BordeneuveTeresa Coelho
Feb 22, 2013·Orphanet Journal of Rare Diseases·Yukio AndoFabrizio Salvi
May 30, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Elisabet IhsePer Westermark
Jan 15, 2014·JACC. Cardiovascular Imaging·Marianna FontanaJames C Moon
Apr 5, 2014·The American Journal of Cardiology·Nowell M FineMartha Grogan
Jun 19, 2014·European Heart Journal Cardiovascular Imaging·David F HuttAshutosh D Wechalekar
Sep 13, 2014·The American Journal of Cardiology·Nicole B CyrilleMathew S Maurer
Sep 30, 2014·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Jean D SipePer Westermark
Dec 17, 2014·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Amanda TendlerMathew S Maurer
Jan 1, 2015·The New England Journal of Medicine·C Cristina QuartaScott D Solomon

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Citations

Mar 20, 2016·The American Journal of the Medical Sciences·Lei ZhaoQuan Fang
May 12, 2016·Journal of Internal Medicine·M AnkarcronaJ W Kelly
Aug 30, 2016·The Canadian Journal of Cardiology·David L NarotskyMathew S Maurer
Sep 2, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sabahat BokhariMathew S Maurer
Jan 11, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Francesca GrazianiFilippo Crea
May 18, 2018·Acta Pharmacologica Sinica·Marco LucianiFederica Del Monte
Aug 3, 2018·European Journal of Heart Failure·Christian GagliardiClaudio Rapezzi
Nov 21, 2018·Expert Review of Cardiovascular Therapy·Aldostefano PorcariGianfranco Sinagra
Feb 27, 2016·F1000Research·Daniel E FormanNanette K Wenger
Jun 19, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Ángela López-SainzPablo Garcia-Pavia
Nov 14, 2019·Circulation. Cardiovascular Imaging·Albree Tower-Rader, Wael A Jaber
Aug 31, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sharmila DorbalaJamieson M Bourque
Jan 28, 2020·Annual Review of Medicine·Jonah Rubin, Mathew S Maurer
Aug 30, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kathleen R FlahertySabahat Bokhari
Feb 9, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rachelle MorgensternSabahat Bokhari
Jun 16, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ray E HershbergerUNKNOWN ACMG Professional Practice and Guidelines Committee
Oct 31, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Daphne L JonkerWalter Noordzij
May 15, 2019·International Journal of Molecular Sciences·Diana Michels da SilvaTobias Graf
Feb 23, 2019·Heart Failure Reviews·Angelos G RigopoulosMichel Noutsias
Mar 23, 2017·European Heart Journal·Esther González-LópezPablo Garcia-Pavia
Dec 7, 2017·Journal of Neurology·Ana Martins da SilvaTeresa Coelho
Mar 11, 2019·Heart Failure Reviews·George MakavosIgnatios Ikonomidis
Jun 12, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Candida Cristina QuartaClaudio Rapezzi
Sep 1, 2016·Academic Forensic Pathology·Susan E Presnell, Cynthia A Schandl
May 2, 2020·Current Heart Failure Reports·Nicholas S HendrenJustin L Grodin
Sep 29, 2020·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Francesco CappelliMaria Beatrice Musumeci
Dec 5, 2019·Herz·Sophie I MavrogeniEfstathios Kastritis
Oct 10, 2020·European Journal of Internal Medicine·Aldostefano PorcariGianfranco Sinagra
Jan 19, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·A YilmazN Frey
Apr 23, 2020·Revista Española De Cardiología·Ángela López-SainzPablo Garcia-Pavia
Oct 31, 2020·BMC Cardiovascular Disorders·Nicolò MartiniAlberto Cipriani
Dec 29, 2020·Frontiers in Molecular Neuroscience·Filipa BezerraMaria Rosário Almeida
Jan 21, 2021·Journal of Personalized Medicine·Emily R SoperNoura S Abul-Husn
Feb 25, 2021·European Journal of Preventive Cardiology·Daniele PasqualucciAndrea Mortara
Mar 18, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matteo BiancoL Montagna

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