Cardiac anaphylaxis: SRS-A potentiates and extends the effects of released histamine

European Journal of Pharmacology
R Levi, J A Burke

Abstract

Immunologic immediate hypersensitivity reactions of the heart are characterized by tachycardia and arrhythmias caused by the release of endogenous cardiac histamine. The contribution of SRS-A to anaphylactic cardiac dysfunction was indirectly assessed by the use of the selective SRS-A receptor antagonist FPL 55712. In the presence of FPL 55712 the concentration-response curves for the chronotropic and arrhythmogenic effects of endogenous cardiac histamine were progressively shifted to the right as a function of the concentration of FPL 55712. Moreover, the duration of the positive chronotropic effect of endogenous cardiac histamine was shortened by FPL 55712. On the other hand, FPL 55712 failed to reduce the chronotropic and arrhythmogenic effects of exogenous histamine. Partially purified histamine-free SRS-A opbtained from rat peritoneum potentiated and greatly prolonged the positive chronotropic effect of exogenous histamine. Potentiation and prolongation were both blocked by FPL 55712. Thus, our results suggest that SRS-A sensitized the heart to the tachyarrhythmic effects of histamine.

References

Jun 1, 1976·Life Sciences·R LeviJ H Zavecz
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
Aug 31, 1959·Acta Physiologica Scandinavica·N CHAKRAVARTY

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Citations

Sep 1, 1982·Klinische Wochenschrift·D LangrehrS Agoston
Oct 1, 1984·Agents and Actions·A G StewartM R Fennessy
Apr 1, 1985·Agents and Actions·E MasiniJ P Gagnol
May 1, 1984·Prostaglandins·G Feuerstein
Jan 1, 1983·International Journal of Immunopharmacology·J F Regal, R J Pickering
Sep 1, 1994·International Journal of Immunopharmacology·N GorenE Borda
Jan 1, 1983·The Journal of Emergency Medicine·W C Lucke, H Thomas
Jun 1, 1985·Journal of Autonomic Pharmacology·G Feuerstein
Mar 1, 1987·British Journal of Pharmacology·P BlandinaE Masini
Jan 1, 1982·Annales Françaises D'anesthèsie Et De Rèanimation·M C LaxenaireS Boileau
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·B A Richards-Smith, R W Elliott
Jan 1, 1990·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H Y Zhao, W Y Fang
Jan 1, 1986·Circulation Research·A A Wolff, R Levi
Mar 5, 2003·Pharmacological Reviews·Charles BrinkTakehiko Yokomizo
May 15, 2018·The Journal of Clinical Investigation·Takehiko YokomizoTakao Shimizu
Jan 1, 1984·Drug Intelligence & Clinical Pharmacy·J J Fath, F B Cerra

❮ Previous
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