Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig

Prostaglandins
D EzraG Z Feuerstein

Abstract

In previous studies we have shown that platelet-activating factor (PAF) is a potent vasoactive substance with deleterious effects on coronary blood flow (CBF) and myocardial performance. The present study further investigates the effects of PAF during its sustained intracoronary infusion in the blood-perfused domestic pig (n = 16). PAF infusion (1-9 nmol/min) produced triphasic changes in CBF (n = 7): an initial brief phase of coronary dilation (14 +/- 2% above baseline), followed by severe reduction in CBF due to increase in coronary vascular resistance and a third phase of escape that was characterized by return of CBF towards baseline in spite of continuing PAF infusion. In 9 remaining pigs PAF infusion had a biphasic response: the first phase of coronary dilation rapidly turned into severe coronary constriction accompanied by severe systemic hypotension and death within a few min. PAF infusion caused a profound rise in systemic arterial and coronary venous thromboxane B2 levels, while 6-keto-PGF1 alpha and leukotriene C4-immunoreactivity levels were not changed. Indomethacin completely blocked the rise in thromboxane level during PAF infusion and abolished the constrictor effect of PAF on the coronary vessels. These data su...Continue Reading

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Citations

Nov 1, 1987·Lipids·H K Mangold, N Weber
Dec 1, 1991·Lipids·R RabinoviciG Feuerstein
Jun 1, 1997·Archives of Pharmacal Research·S Y SonH W Chang
May 1, 1984·Prostaglandins·G Feuerstein
Apr 1, 1991·Trends in Cardiovascular Medicine·M R HollandS M Prescott
Mar 1, 1997·Journal of Lipid Mediators and Cell Signalling·G FeuersteinS Vonhof
May 1, 1992·The Journal of Clinical Investigation·R RabinoviciG Feuerstein
Feb 25, 2009·International Journal of Cardiology·Dan ZhaoBao-Feng Yang
May 1, 1992·Circulation Research·S YamanakaK Yamamoto
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S B FelixW E Berdel
Oct 4, 2000·Physiological Reviews·G MontrucchioG Camussi
Jan 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M Evangelou

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