PMID: 6540101Jan 1, 1984Paper

Cardiac and hemodynamic effects of the centrally acting analgesics tramadol and pentazocine in anaesthetized rabbits and isolated guinea-pig atria and papillary muscles

Arzneimittel-Forschung
B Müller, K Wilsmann

Abstract

Cardio-hemodynamic and direct cardiac effects of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)- cyclohexan -1-ol (tramadol, Tramal ), and pentazocine were investigated in anaesthetized rabbits and in isolated guinea-pig atria and papillary muscles. Tramadol in anaesthetized rabbits at 1 and 4.64 mg/kg i.v. slightly increased arterial blood pressure and heart rate and at 10 mg/kg i.v. transiently decreased blood pressure, LV dp/dtmax and cardiac output and increased LV enddiastolic pressure. Pentazocine at 1 mg/kg i.v. increased blood pressure and peripheral vascular resistance, while with 2.15 and 4.64 mg/kg exerted dose-dependent cardiodepressive effects with initial fall of blood pressure, heart rate, LV dp/dtmax and cardiac output and increase of LV enddiastolic pressure. In spontaneously beating atria and electrically driven papillary muscles tramadol in the concentration range from 1 X 10(-6)-1 X 10(-4) mol/l showed concentration-dependent positive inotropic effects which where abolished and reversed to negative inotropic actions in catecholamine-depleted papillary muscles. In contrast, pentazocine in the same concentration range showed pure negative inotropic and negative chronotropic effects which were intensified in catec...Continue Reading

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