Cardiac and kidney hormones cure up to 86% of human small-cell lung cancers in mice

European Journal of Clinical Investigation
E J EichelbaumD L Vesely

Abstract

Four cardiac hormones synthesized by the same gene, i.e. atrial natriuretic peptide, vessel dilator, long acting natriuretic peptide and kaliuretic peptide, and the kidney hormone urodilatin have anticancer effects in vitro. These cardiac hormones and urodilatin were infused subcutaneously for 28 days with weekly fresh hormones since they lose biological effects at body temperature for more than a week at 0.3 nm kg(-1) body weight in athymic mice bearing human small-cell lung carcinomas. Long acting natriuretic peptide, vessel dilator, kaliuretic peptide, atrial natriuretic peptide and urodilatin eliminated 86%, 71%, 57%, 43% (P < 0.001 for the cardiac hormones) and 25% (P < 0.05; urodilatin) of the human small-cell lung carcinomas. The treated small-cell lung carcinomas that were not cured grew rapidly, similar to the untreated controls, whose volume was 7 fold larger in 1 week, 18-fold increased in 2 weeks, 39-fold increased in 3 weeks, 63-fold increased in 1 month and 97-fold increased in volume in 6 weeks. One vessel dilator treated small-cell lung carcinoma animal developed a large tumour (8428 mm3 volume) on treatment and this tumour was eliminated with utilizing atrial natriuretic peptide and then long acting natriuretic...Continue Reading

References

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May 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sabiha R SabaDavid L Vesely
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Citations

Mar 28, 2013·Endocrine-related Cancer·David L Vesely
Sep 25, 2016·Protein Expression and Purification·Mahdi AbbasianReza Zareie
Dec 28, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·N I SolovyevaE V Kugaevskaya
Apr 27, 2010·European Journal of Clinical Investigation·A LenzD L Vesely
Apr 1, 2010·European Journal of Clinical Investigation·Ying SunDavid L Vesely
Jun 19, 2012·European Journal of Clinical Investigation·Jennifer P NguyenDavid L Vesely
Jun 4, 2014·Clinical and Experimental Pharmacology & Physiology·Qingyu ZhouDavid L Vesely
Sep 12, 2012·Molecular and Cellular Biochemistry·Meghan L LaneDavid L Vesely
Feb 15, 2013·Experimental and Therapeutic Medicine·William P SkeltonDavid L Vesely
Jan 18, 2013·American Journal of Physiology. Renal Physiology·Lai-Jing GuoHui-Fang Bao
Sep 3, 2013·European Journal of Clinical Investigation·Neil J ManimalaDavid L Vesely
Jul 9, 2021·Biomedical Journal·Mengjiao XuGeng Yang

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