Cardiac and renal baroreflex control during stress in conscious renovascular hypertensive rabbits: effect of rilmenidine

Journal of Hypertension
Sandra L Burke, Goeffrey A Head

Abstract

We examined whether renal sympathetic nerve activity (RSNA) and heart rate (HR) baroreflexes in conscious rabbits were altered by exposure to a combination of stress and hypertension and determined how this was modified by acute and chronic treatment with the sympathoinhibitory agent rilmenidine. Rabbits were made hypertensive with a renal-artery clip and a renal nerve recording electrode was implanted 4-5 weeks later. After recovery, baroreflexes were measured before and during airjet stress and again after receiving rilmenidine (either acutely or by infusion for 3 weeks). Renal clipping increased mean arterial pressure (MAP) and shifted baroreflex RSNA and HR curves rightward. The HR and RSNA upper plateaus were similar to those of normotensive animals but HR baroreflex sensitivity was reduced in the hypertensive group. Airjet stress lowered HR baroreflex sensitivity in sham but not in hypertensive rabbits. By contrast, stress increased the baroreflex-induced maximum RSNA in hypertensive animals but not in normotensive rabbits. MAP variability was greater in the hypertensive group but was unaffected by airjet stress. Acute and chronic rilmenidine lowered MAP to close to normotensive levels, markedly reduced MAP variability an...Continue Reading

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Citations

Aug 25, 2009·Experimental Physiology·Sarah-Jane GuildSimon C Malpas
Mar 6, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Renata V TiradentesSonia A Gouvea
Jun 1, 2012·Hypertension·James A ArmitageGeoffrey A Head
Dec 4, 2008·Journal of Hypertension·Claude Julien
Feb 11, 2010·Traffic Injury Prevention·David K JonesSemra A Aytur
Jan 19, 2012·Journal of Hypertension·John-Luis MorettiGeoffrey A Head
Jun 5, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger A L Dampney
Feb 25, 2011·Journal of Hypertension·Sandra L BurkeGeoffrey A Head
Jun 5, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Alina ScridonPhilippe Chevalier
Feb 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Sandra L BurkeGeoffrey A Head
Jan 20, 2021·Fundamental & Clinical Pharmacology·Michelle M MendonçaCarlos Henrique Xavier

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