Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse.

Journal of Biomedical Science
Elisardo C VasquezSilvana S Meyrelles

Abstract

Cardiovascular death is frequently associated with atherosclerosis, a chronic multifactorial disease and a leading cause of death worldwide. Genetically engineered mouse models have proven useful for the study of the mechanisms underlying cardiovascular diseases. The apolipoprotein E-deficient mouse has been the most widely used animal model of atherosclerosis because it rapidly develops severe hypercholesterolemia and spontaneous atherosclerotic lesions similar to those observed in humans. In this review, we provide an overview of the cardiac and vascular phenotypes and discuss the interplay among nitric oxide, reactive oxygen species, aging and diet in the impairment of cardiovascular function in this mouse model.

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Citations

Jun 22, 2013·DNA and Cell Biology·Bianca P CampagnaroSilvana S Meyrelles
Apr 4, 2013·Cardiovascular Diabetology·Matilde E Otero-LosadaJosé Milei
Aug 2, 2012·Lipids in Health and Disease·Leandro C F LimaSilvana S Meyrelles
Aug 29, 2013·Lipids in Health and Disease·Bianca P RodriguesElisardo C Vasquez
Jan 8, 2013·Journal of Translational Medicine·Camille M BalariniElisardo C Vasquez
Feb 8, 2014·Journal of Translational Medicine·Ananda T DiasElisardo C Vasquez
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May 28, 2016·Lipids in Health and Disease·Franciane P BernardesSilvana S Meyrelles
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Methods Mentioned

BETA
transgenic
environmental stress

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