Cardiac and vasomotor components of the carotid baroreflex control of arterial blood pressure during isometric exercise in humans

The Journal of Physiology
James P FisherMichael J White

Abstract

We sought to examine the importance of the cardiac component of the carotid baroreflex (CBR) in control of blood pressure during isometric exercise. Nine subjects performed 4 min of ischaemic isometric calf exercise at 20% of maximum voluntary contraction. Trials were repeated with beta1-adrenergic blockade (metoprolol, 0.15 +/- 0.003 mg kg(-1)) or parasympathetic blockade (glycopyrrolate, 13.6 +/- 1.5 microg kg(-1)). CBR function was determined using rapid pulses of neck pressure and neck suction from +40 to -80 mmHg, while heart rate (HR), mean arterial pressure (MAP) and changes in stroke volume (SV, Modelflow method) were measured. Metoprolol decreased and glycopyrrolate increased HR and cardiac output both at rest and during exercise (P < 0.05), while resting and exercising blood pressure were unchanged. Glycopyrrolate reduced the maximal gain (G(max)) ofthe CBR-HR function curve (-0.58 +/- 0.10 to -0.06 +/- 0.01 beats min(-1) mmHg(-1), P < 0.05), but had no effect on the G(max) of the CBR-MAP function curve. During isometric exercise the CBR-HR curve was shifted upward and rightward in the metoprolol and no drug conditions, while the control of HR was significantly attenuated with glycopyrrolate (P < 0.05). Regardless of ...Continue Reading

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Citations

Feb 21, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Victoria L Cooper, Roger Hainsworth
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Shigehiko OgohPaul J Fadel
Sep 22, 2010·European Journal of Applied Physiology·Helmut Hinghofer-Szalkay
Feb 10, 2010·The Journal of Physiology·James P FisherPaul J Fadel
Oct 20, 2009·Experimental Physiology·John H Coote
May 17, 2011·The American Journal of Emergency Medicine·Te-Fa ChiuWei-Lung Chen
Sep 15, 2016·Physiological Reports·Jane M BlackJoseph I Esformes
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·James P FisherPaul J Fadel
Jun 23, 2007·Journal of Applied Physiology·James P FisherPaul J Fadel
Aug 18, 2020·Medicine and Science in Sports and Exercise·Sara R ShermanThessa I M Hilgenkamp

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