Cardiac and venous blood flow in fetuses of insulin-dependent diabetic mothers: evidence of abnormal hemodynamics in early gestation

American Journal of Obstetrics and Gynecology
G RizzoC Romanini

Abstract

Our purpose was to determine whether in early gestation cardiac and venous blood flow patterns of fetuses of insulin-dependent diabetic mothers differ from those of normal fetuses. Serial recordings were obtained at 12, 16, and 20 weeks of gestation in 11 normal fetuses, 16 fetuses of insulin-dependent diabetic mothers with first-trimester glycosylated hemoglobin levels < or = 8.5% (group 1), and 11 fetuses of insulin-dependent diabetic mothers with first-trimester glycosylated hemoglobin levels > 8.5% (group 2). Velocity waveforms at the level of atrioventricular valves, inferior vena cava, and umbilical vein were recorded by means of color and pulsed Doppler equipment by either transvaginal or transabdominal approaches. The following variables were measured: ratio between the peak velocities during early passive ventricular filling and active atrial filling at the level of atrioventricular valves, percent reverse flow during atrial contraction in inferior vena cava, and pulsations in umbilical vein. In all the fetuses the ratios between early and active ventricular filling increased linearly with advancing gestation, whereas the percent reverse flow in the inferior vena cava decreased linearly. However, fetuses of diabetic mo...Continue Reading

References

Oct 27, 1977·The New England Journal of Medicine·A V Thorsson, R L Hintz
Sep 1, 1992·American Journal of Obstetrics and Gynecology·G RizzoC Romanini
Sep 1, 1992·American Journal of Obstetrics and Gynecology·J W WladimiroffT Stijnen
Jan 1, 1991·The Journal of Pediatrics·H S WeberC S Kleinman
Mar 1, 1991·American Journal of Obstetrics and Gynecology·G RizzoC Romanini
Oct 1, 1988·American Journal of Perinatology·M D Reller, S Kaplan
Dec 15, 1985·American Journal of Obstetrics and Gynecology·S G Gabbe
Nov 1, 1992·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G RizzoC Romanini
Jul 1, 1992·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T W HuismanJ W Wladimiroff

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Citations

Jun 11, 1999·Obstetrics and Gynecology·Z WeinerJ Itskovitz-Eldor
Sep 23, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P GrecoL Selvaggi
Nov 28, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·J StinstraM J Peters
May 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R Chaoui
Jul 1, 1998·British Journal of Obstetrics and Gynaecology·N S MacklonJ W Wladimiroff
May 16, 2006·Heart·L K Hornberger
Jun 20, 2013·Pediatric Cardiology·Sevket BalliÖmer Kandemir
Oct 15, 2013·Prenatal Diagnosis·Tim Van MieghemGreg Ryan
May 4, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S TuranA A Baschat
Apr 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Derya ArslanOsman Guvenc
Sep 6, 2008·American Journal of Obstetrics and Gynecology·Noirin E RussellFionnuala M McAuliffe
Feb 2, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Noirin E RussellFionnuala M McAuliffe
Apr 22, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L A LisowskiE J Meijboom
May 28, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C Firpo, P Zielinsky
Jul 3, 2018·Frontiers in Physiology·Cheryl L Maslen
Mar 3, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M L WongY F Cheung
May 4, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Gökalp ŞenolMehmet Aytaç Yüksel
Aug 24, 2021·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Angelo SiricoAntonio Lanzone

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