Cardiac Arrest Outcomes in Children With Preexisting Neurobehavioral Impairment

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
James R ChristensenTherapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators

Abstract

To describe survival and 3-month and 12-month neurobehavioral outcomes in children with preexisting neurobehavioral impairment enrolled in one of two parallel randomized clinical trials of targeted temperature management. Secondary analysis of Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital and Out-of-Hospital trials data. Forty-one PICUs in the United States, Canada, and United Kingdom. Eighty-four participants (59 in-hospital cardiac arrest and 25 out-of-hospital cardiac arrest), 49 males, 35 females, mean age 4.6 years (SD, 5.36 yr), with precardiac arrest neurobehavioral impairment (Vineland Adaptive Behavior Scales, Second Edition composite score < 70). All required chest compressions for greater than or equal to 2 minutes, were comatose and required mechanical ventilation after return of circulation. Neurobehavioral function was assessed using the Vineland Adaptive Behavior Scales, Second Edition at baseline (reflecting precardiac arrest status), and at 3 and 12 months postcardiac arrest, followed by on-site cognitive evaluation. Vineland Adaptive Behavior Scales, Second Edition norms are 100 (mean) ± 15 (SD); higher scores indicate better function. Analyses evaluated survival, changes in Vineland Adapt...Continue Reading

References

Jul 1, 1992·The Journal of Pediatrics·D H Fiser
May 1, 1994·Pediatric Neurology·R L KrielJ Sanchez
Mar 21, 2002·Intensive Care Medicine·T HorisbergerS Fanconi
Oct 31, 2006·Resuscitation·James Tibballs, Sharon Kinney
Jan 22, 2008·Resuscitation·Agnieszka MaryniakMaria Knecht
May 21, 2009·Critical Care Medicine·Frank W MolerUNKNOWN Pediatric Emergency Care Applied Research Network
May 13, 2011·Science Translational Medicine·Ann S Williams, Shirley M Moore
Apr 29, 2015·The New England Journal of Medicine·Frank W MolerUNKNOWN THAPCA Trial Investigators
Aug 25, 2015·Resuscitation·Jimena Del CastilloUNKNOWN Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI
Mar 5, 2016·Pediatrics·Beth S SlomineUNKNOWN THAPCA Trial Group
Sep 30, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kathleen L MeertUNKNOWN Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators
Nov 8, 2016·JAMA Pediatrics·Farhan BhanjiUNKNOWN American Heart Association’s Get With the Guidelines–Resuscitation Investigators
Jan 25, 2017·The New England Journal of Medicine·Frank W MolerUNKNOWN THAPCA Trial Investigators
Mar 10, 2017·Resuscitation·Beth S SlomineUNKNOWN Therapeutic Hypothermia after Pediatric Cardiac Arrest THAPCA Trial Investigators
Jan 7, 2018·Resuscitation·Beth S SlomineUNKNOWN Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigators

❮ Previous
Next ❯

Citations

Jun 5, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rachel S Agbeko
Nov 7, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nobuaki Shime

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Kathleen L MeertTherapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators
Critical Care Medicine
Kathleen L MeertTherapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trial Investigators
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Richard HolubkovJ Michael Dean
Revista española de cardiología
Daniel J Fenández-Bergés Gurrea
© 2022 Meta ULC. All rights reserved