Cardiac assessment in Wilson's disease patients based on electrocardiography and echocardiography examination

Archives of Medical Science : AMS
Małgorzata Buksińska-LisikAnna Członkowska

Abstract

Wilson's disease (WD) is a rare genetic disorder that leads to impairments in copper metabolism. Patients principally exhibit liver and neuropsychiatric symptoms, but because copper also accumulates in all body organs, other (typically milder) clinical symptoms can occur. To date, cardiac involvement has not been thoroughly investigated in patients with WD. This study aimed to evaluate heart structure and function in patients with WD with commonly available diagnostic methods. We compared 125 WD patients with an age- and sex-matched control group. Patients with WD were grouped according to their dominant symptoms - neurologic or hepatic. All subjects underwent clinical, electrocardiographic (ECG), and echocardiographic examinations. All subjects had sinus rhythm on electrocardiography. The only ECG parameter that differed between patients with WD and the control group was the QRS prolongation (92.0 vs. 86.4 ms; p < 0.05). On echocardiography patients with WD exhibited more hypertrophy in the left ventricle than controls (posterior wall in diastole: 1.0 vs. 0.93; p < 0.01) and the left ventricle hypertrophy was more pronounced in the neurologic than in the hepatic subgroup (1.05 vs. 0.96 cm; p < 0.01). Left ventricular systolic ...Continue Reading

Citations

Jun 11, 2020·Current Opinion in Neurology·Annu Aggarwal, Mohit Bhatt
Sep 8, 2018·Nature Reviews. Disease Primers·Anna CzłonkowskaMichael L Schilsky
Jul 14, 2020·Current Opinion in Neurology·Annu Aggarwal, Mohit Bhatt
Aug 25, 2020·Liver Research·Tagreed A MaziValentina Medici
Apr 14, 2020·Neurologic Clinics·Caitlin Mulligan, Jeff M Bronstein
Jun 25, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Janek SalatzkiMarco Ochs
Jul 27, 2021·Movement Disorders Clinical Practice·Malco RossiMarcelo Merello
Jul 22, 2021·Journal of Inherited Metabolic Disease·Kevin ChevalierAurélia Poujois

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