Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy

Autoimmunity
A L CaforioW J Mckenna

Abstract

Dilated cardiomyopathy (DCM) is characterized by dilation and impaired contraction of the left ventricle or both; it is a relevant cause of heart failure and a common indication for heart transplantation. It may be idiopathic, familial/genetic, viral, autoimmune or immune-mediated, associated with a viral infection. Myocarditis is an inflammatory disease of the myocardium; it may be idiopathic, infectious or autoimmune and may heal or lead to DCM. Thus, in a patient subset, myocarditis and DCM are thought to represent the acute and chronic stages of an organ-specific autoimmune disease of the myocardium. In keeping with this hypothesis, autoimmune features in patients with myocarditis/DCM include: familial aggregation, a weak association with HLA-DR4, abnormal expression of HLA class II on cardiac endothelium on endomyocardial biopsy, detection of organ- and disease-specific cardiac autoantibodies in the sera of affected patients and of symptom-free relatives. The organ-specific cardiac autoantibodies detected by immunofluorescence are directed against multiple antigens. One of these, first identified using immunoblotting and confirmed by ELISA, is the cardiac-specific alpha-myosin isoform. Myosin fulfils the expected criteria ...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S C Smith, P M Allen
Jun 1, 1990·Journal of the American College of Cardiology·A L CaforioW J McKenna
Nov 1, 1990·Journal of the American College of Cardiology·D A NeumannA Herskowitz
Dec 1, 1994·British Heart Journal·A L Caforio
Oct 1, 1996·Drugs·A L Caforio, W J McKenna
Jul 10, 1999·Journal of the American College of Cardiology·L Mestroni Camerini
Jan 13, 2000·Current Opinion in Immunology·M M GriffithsR L Wilder
Jul 21, 2000·The Journal of Clinical Investigation·J E GalvinM W Cunningham

❮ Previous
Next ❯

Citations

May 16, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Angela Kallwellis-OparaMathias Pauschinger
Sep 18, 2009·Basic Research in Cardiology·Antje VoigtAlexander Staudt
Oct 15, 2009·Journal of Clinical Immunology·Noel R Rose
Nov 11, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Kun LiuZhaohui Wang
Jan 12, 2011·Current Heart Failure Reports·Jose H Flores-ArredondoGuillermo Torre-Amione
Dec 8, 2005·Hybridoma·P N NelsonC Spry
Jan 1, 2009·BMJ Case Reports·Torsten Bloch RasmussenJens Erik Nielsen-Kudsk
Nov 30, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Mototsugu NishiiToru Izumi
Jan 30, 2010·Progress in Cardiovascular Diseases·Lori A Blauwet, Leslie T Cooper
Jun 9, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Rosemary C She, Elizabeth H Hammond
Feb 24, 2009·Journal of Molecular and Cellular Cardiology·Takaaki HagaToshimitsu Uede
Dec 3, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji Shiba
Mar 6, 2007·Journal of Autoimmunity·Philippe KrebsBurkhard Ludewig
Jul 11, 2009·Journal of Clinical Apheresis·Andreas O DoeschThomas J Dengler
Jun 16, 2010·European Journal of Clinical Investigation·Christiane TrimpertAlexander Staudt
Dec 4, 2012·Clinical and Experimental Immunology·Y ZhangF Gao
Sep 9, 2010·Journal of Clinical Apheresis·Andreas O DoeschHugo A Katus
Jul 1, 2008·American Heart Journal·Martin LandsbergerStephan B Felix
Jun 1, 2005·The American Journal of Cardiology·Guillermo Torre-Amione
Aug 30, 2005·Journal of Immunological Methods·Reinhard MaierBurkhard Ludewig
Dec 19, 2014·PLoS Neglected Tropical Diseases·Maria C GuimaroAntonio R L Teixeira
Apr 9, 2013·Current Protocols in Immunology·Jennifer M MyersMadeleine W Cunningham
Feb 16, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Agnes PetrohaiTimea Berki
May 19, 2018·Cardiovascular & Hematological Disorders Drug Targets·Amrita Sarkar, Khadija Rafiq
Feb 4, 2006·Autoimmunity·Sally A Huber
Sep 11, 2008·Autoimmunity·Adita Mascaro-BlancoMadeleine W Cunningham
Oct 10, 2014·International Heart Journal·Xin GongWenwei Yang
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ya LiMadeleine W Cunningham
Nov 3, 2017·Frontiers in Immunology·Katherine V GatesLeigh G Griffiths

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.