Cardiac autonomic neuropathy in type 1 and type 2 diabetes patients

BMC Neurology
Anca MoţăţăianuAdina Stoian

Abstract

Cardiac autonomic neuropathy (CAN) in diabetes is among the strongest risk markers for future global and cardiovascular mortality. The aim of this study was to analyse CAN prevalence and to compare the associations between CAN, the glycaemic control, cardiovascular risk factors, peripheral neuropathy, retinopathy and macroangiopathy in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM). One hundred ninety-five diabetic patients were included in this study. All patients were evaluated for detection of CAN (with standardised cardiovascular reflex tests), diabetes-related microvascular complications (polyneuropathy, retinopathy), common carotid artery intima-media thickness (IMT) and ankle-brachial index (ABI). The prevalence of CAN was 39.1% in T2DM and 61.8% in T1DM patients. Multivariate logistic regression analysis demonstrated that in T2DM, the odds [OR (95% confidence intervals)] of CAN increased with diabetes duration [1.67(1.42-1.92)], HbA1c [1.74(1.34-2.27)], cholesterol [1.01(1.00-1.01)], triglycerides [1.01(0.99-1.00)], smoking [2.35(1.23-4.49)], systolic blood pressure [1.01(1.00-1.03)], BMI [1.16(1.08-1.24)], glomerular filtration rate [0.91(0.88-0.93)], peripheral neuropathy [25.94(11.04-44.25)], retinop...Continue Reading

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Citations

Jan 28, 2019·International Journal of Adolescent Medicine and Health·Aminolah VasighAsma Tarjoman
May 10, 2020·International Journal of Environmental Research and Public Health·Mozania Reis de MatosMaria Lucia Correa-Giannella
Oct 28, 2019·Cardiovascular Endocrinology & Metabolism·Harish SharmaParth Narendran
Nov 10, 2020·Diabetologia·Aikaterini EleftheriadouUazman Alam
Nov 11, 2020·Scientific Reports·José Ángel García-PedrazaCarlos M Villalón
Dec 8, 2020·Annals of Internal Medicine·Caitlin W HicksElizabeth Selvin
Apr 4, 2021·Journal of Personalized Medicine·Mar Sempere-BigorraOmar Cauli
Aug 28, 2021·International Journal of Molecular Sciences·Valentina AlfieriPaolo Poggio

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