Cardiac biomarkers in acute myocardial infarction

International Journal of Cardiology
Sally J Aldous

Abstract

Each year, a large number of patients are seen in the Emergency Department with presentations necessitating investigation for possible acute myocardial infarction. Patients can be stratified by symptoms, risk factors and electrocardiogram results but cardiac biomarkers also have a prime role both diagnostically and prognostically. This review summarizes both the history of cardiac biomarkers as well as currently available (established and novel) assays. Cardiac troponin, our current "gold standard" biomarker criterion for the diagnosis of myocardial infarction has high sensitivity and specificity for this diagnosis and therapies instituted in patients with elevated troponin have been shown to influence outcomes. Other markers of myocardial necrosis, inflammation and neurohormonal activity have also been shown to have either diagnostic or prognostic utility, but none have been shown to be superior to troponin. The measurement of multiple biomarkers and the use of point of care markers may accelerate current diagnostic protocols for the assessment of such patients.

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Citations

Feb 28, 2013·Sensors·Dragos Amarie, James A Glazier
Oct 23, 2014·International Journal of Critical Illness and Injury Science·Noopur Singhal, Abhijeet Saha
Jun 21, 2016·Heart, Lung & Circulation·Baowei ZhangYawei Xu
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Dec 15, 2015·Biosensors & Bioelectronics·Babak RezaeiMohammad Rabiee
May 11, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zhe WangZhen Dong
May 7, 2013·International Journal of Cardiology·Alberto Dominguez-RodriguezPedro Abreu-Gonzalez
Jan 21, 2014·International Journal of Cardiology·Giuseppe Lippi, Gianfranco Cervellin
Jul 19, 2014·International Journal of Cardiology·Giuseppe LippiGianfranco Cervellin
Apr 5, 2014·International Journal of Cardiology·Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez
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