Cardiac biomarkers in chronic kidney disease are independently associated with myocardial edema and diffuse fibrosis by cardiovascular magnetic resonance.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
Luca ArcariValentina O Puntmann

Abstract

High sensitivity cardiac troponin T (hs-cTnT) and NT-pro-brain natriuretic peptide (NT-pro BNP) are often elevated in chronic kidney disease (CKD) and associated with both cardiovascular remodeling and outcome. Relationship between these biomarkers and quantitative imaging measures of myocardial fibrosis and edema by T1 and T2 mapping remains unknown. Consecutive patients with established CKD and estimated glomerular filtration rate (eGFR) < 59 ml/min/1.73 m2 (n = 276) were compared to age/sex matched patients with eGFR ≥ 60 ml/min/1.73 m2 (n = 242) and healthy controls (n = 38). Comprehensive cardiovascular magnetic resonance (CMR) with native T1 and T2 mapping, myocardial ischemia and scar imaging was performed with venous sampling immediately prior to CMR. Patients with CKD showed significant cardiac remodeling in comparison with both healthy individuals and non-CKD patients, including a stepwise increase of native T1 and T2 (p < 0.001 between all CKD stages). Native T1 and T2 were the sole imaging markers independently associated with worsening CKD in patients [B = 0.125 (95% CI 0.022-0.235) and B = 0.272 (95% CI 0.164-0.374) with p = 0.019 and < 0.001 respectively]. At univariable analysis, both hs-cTnT and NT-pro BNP sign...Continue Reading

References

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Nov 12, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Darius DabirValentina O Puntmann
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Nov 6, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rodrigo Fernández-JiménezBorja Ibáñez
Jan 15, 2016·JACC. Cardiovascular Imaging·Valentina O PuntmannUNKNOWN International T1 Multicentre CMR Outcome Study
Jul 6, 2016·European Heart Journal Cardiovascular Imaging·Frederik H VerbruggeDavid Verhaert
Aug 27, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Gianni PedrizzettiEike Nagel
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Mar 3, 2018·Current Cardiovascular Imaging Reports·Kenneth MangionElaine Rutherford
Aug 31, 2018·European Heart Journal·Kristian ThygesenUNKNOWN ESC Scientific Document Group
Sep 21, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Valentina O PuntmannUNKNOWN SCMR Clinical Trial Writing Group
Jun 20, 2019·The New England Journal of Medicine·Eike NagelUNKNOWN MR-INFORM Investigators
Feb 25, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher M KramerEike Nagel

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