Cardiac Biomarkers in the Emergency Department: The Role of Soluble ST2 (sST2) in Acute Heart Failure and Acute Coronary Syndrome-There is Meat on the Bone

Journal of Clinical Medicine
Aneta AleksovaAlan S Maisel

Abstract

Soluble ST2 (sST2) has recently emerged as a promising biomarker in the field of acute cardiovascular diseases. Several clinical studies have demonstrated a significant link between sST2 values and patients' outcome. Further, it has been found that higher levels of sST2 are associated with an increased risk of adverse left ventricular remodeling. Therefore, sST2 could represent a useful tool that could help the risk stratification and diagnostic and therapeutic work-up of patients admitted to an emergency department. With this review, based on recent literature, we have built sST2-assisted flowcharts applicable to three very common clinical scenarios of the emergency department: Acute heart failure, type 1, and type 2 acute myocardial infarction. In particular, we combined sST2 levels together with clinical and instrumental evaluation in order to offer a practical tool for emergency medicine physicians.

References

Apr 12, 2005·The American Journal of Cardiology·James L JanuzziKent B Lewandrowski
Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Joerg Heineke, Jeffery D Molkentin
Feb 13, 2008·The Journal of Experimental Medicine·Ashley M MillerFoo Y Liew
May 21, 2008·PharmacoEconomics·Lawrence LiaoDavid J Whellan
Nov 11, 2008·Journal of Cardiac Failure·Saskia BoisotRobert L Fitzgerald
Dec 20, 2008·Journal of the American College of Cardiology·Jozef BartunekEllen O Weinberg
Feb 2, 2010·Journal of the American College of Cardiology·Robin A P WeirJohn J V McMurray
Sep 2, 2010·Journal of Internal Medicine·T SocratesC Mueller
Mar 2, 2011·Pharmacology & Therapeutics·Ashley M Miller, Foo Y Liew
Nov 19, 2011·Clinical Chemistry·Payal KohliDavid A Morrow
Feb 27, 2013·The Open Biomarkers Journal·Queen Henry-OkaforAlan B Storrow
Nov 19, 2013·Journal of Cardiac Failure·Tobias BreidthardtChristian Mueller
Nov 23, 2013·Journal of Cardiac Failure·Antoni Bayes-GenisJosep Lupón
Dec 18, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco Matteo CicconePietro Scicchitano
Feb 18, 2014·Journal of the American College of Cardiology·Christopher M Kramer
Dec 4, 2014·International Journal of Cardiology·Susan E PiperTheresa A McDonagh
Feb 11, 2015·The American Journal of Cardiology·James L JanuzziSalvatore Di Somma
Feb 16, 2015·The American Journal of Cardiology·Alan S MaiselChristian Mueller
Sep 1, 2015·Experimental Dermatology·James S LeeKiarash Khosrotehrani
Jan 14, 2016·Arquivos brasileiros de cardiologia·Humberto Villacorta, Alan S Maisel
Jan 20, 2016·Nature Immunology·Nikolas T Martin, Michael U Martin
Jun 22, 2016·Cell and Tissue Research·Virpi Talman, Heikki Ruskoaho
Dec 29, 2016·European Heart Journal·Alan S Maisel, Salvatore Di Somma
Jan 21, 2017·Journal of Cardiovascular Medicine·Dragana RadovanovicPaul Erne
Mar 28, 2017·The American Journal of Medicine·William S JenkinsMaurice Enriquez-Sarano
Apr 30, 2017·Biochemical Pharmacology·Punniyakoti T VeeraveeduTetsuo Minamino
Aug 9, 2017·Emergency Medicine Journal : EMJ·Jaimi H GreensladeLouise Cullen
Aug 9, 2017·Cardiac Failure Review·Gianluigi Savarese, Lars H Lund
Sep 26, 2017·International Journal of Cardiology·Santeri NortamoJuha Perkiömäki
Nov 4, 2017·Journal of the American College of Cardiology·Laura C van VarkUNKNOWN TRIUMPH Investigators
Nov 19, 2017·Circulation·Andrew R ChapmanNicholas L Mills

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Citations

Sep 17, 2019·European Journal of Clinical Investigation·Elena Arellano-OrdenRudolph Schutte
Jul 2, 2020·Clinical Pharmacology : Advances and Applications·Negar FirouzabadiEhsan Bahramali
Aug 28, 2021·Biomolecules·Ana Merino-MerinoJose-Angel Perez-Rivera

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