Cardiac cell therapy: boosting mesenchymal stem cells effects.

Stem Cell Reviews and Reports
E SamperP Sepúlveda

Abstract

Acute myocardial infarction is a major problem of world public health and available treatments have limited efficacy. Cardiac cell therapy is a new therapeutic strategy focused on regeneration and repair of the injured cardiac muscle. Among different cell types used, mesenchymal stem cells (MSC) have been widely tested in preclinical studies and several clinical trials have evaluated their clinical efficacy in myocardial infarction. However, the beneficial effects of MSC in humans are limited due to poor engraftment and survival of these cells, therefore ways to overcome these obstacles should improve efficacy. Different strategies have been used, such as genetically modifying MSC, or preconditioning the cells with factors that potentiate their survival and therapeutic mechanisms. In this review we compile the most relevant approaches used to improve MSC therapeutic capacity and to understand the molecular mechanisms involved in MSC mediated cardiac repair.

References

Jan 1, 1990·Annual Review of Immunology·J Van Snick
Nov 1, 1971·Transfusion·E A LuriaA Y Friedenstein
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·R F PereiraD J Prockop
Jun 1, 1995·The Journal of Cell Biology·R Zarnegar, G K Michalopoulos
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer
May 20, 1998·Current Biology : CB·T I KoblizekW Risau
Jan 1, 1997·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Z GalzieJ A Smith
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Apr 2, 1999·Science·M F PittengerD R Marshak
Apr 25, 2000·The Journal of Laboratory and Clinical Medicine·Y SunS Lamparter
Jun 10, 2000·British Journal of Haematology·A EricesJ J Minguell
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·S GronthosS Shi
Apr 3, 2001·Trends in Pharmacological Sciences·M J Cross, L Claesson-Welsh
May 10, 2001·Cell Structure and Function·M Shibuya
May 31, 2001·The Journal of Cell Biology·S A KuznetsovP G Robey
Aug 18, 2001·Arthritis and Rheumatism·C De BariF P Luyten
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Dec 18, 2001·Cardiovascular Research·Nikolaos G FrangogiannisMark L Entman
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ichiro SekiyaDarwin J Prockop
Jun 25, 2002·The Annals of Thoracic Surgery·Jay G ShakeBradley J Martin
Feb 22, 2003·Journal of Biomedical Science·Manas K MajumdarJoseph D Mosca
Aug 6, 2003·Blood·Pieternella S In 't AnkerHumphrey H H Kanhai
Aug 22, 2003·The New England Journal of Medicine·Henning R AndersenUNKNOWN DANAMI-2 Investigators
Aug 30, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hai-Feng DuanLi-Sheng Wang
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·K H GrinnemoK Le Blanc
Jun 23, 2004·Cytokine & Growth Factor Reviews·Michelle Tallquist, Andrius Kazlauskas
Jun 26, 2004·Circulation Research·Min NianPeter Liu
Dec 8, 2004·Stem Cells·Pieternella S In 't AnkerHumphrey H H Kanhai
Jul 28, 2005·Journal of Inflammation·Jennifer M RyanBernard P Mahon
Oct 4, 2005·Journal of the American College of Cardiology·Yao Liang TangM Ian Phillips
Oct 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Vincent F M SegersGilles W De Keulenaer

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Citations

Aug 10, 2012·Stem Cells and Development·Inmaculada CerradaPilar Sepúlveda
Apr 8, 2014·Tissue Engineering. Part a·Amr A AbdeenKristopher A Kilian
Oct 18, 2014·Cytotechnology·Nareshwaran GnanasegaranNoor Hayaty Abu Kasim
Dec 23, 2014·Expert Opinion on Biological Therapy·Yang Liu, Dong-An Wang
Mar 20, 2015·Tissue Engineering. Part B, Reviews·Melanie L HartJan E Brinchmann
Jun 25, 2015·Stem Cell Research & Therapy·Fernando EzquerSebastián D Calligaris
Sep 10, 2014·Journal of the American Chemical Society·Megan E MuroskiGeoffrey F Strouse
Jan 6, 2018·Npj Regenerative Medicine·Elena CambriaMaximilian Y Emmert
Apr 20, 2020·Stem Cell Reviews and Reports·Stella Souza VieiraAndrey Jorge Serra
Jul 26, 2014·Molecular and Cellular Biochemistry·Yeyou LiangWeiwei Yuan
Dec 11, 2020·Stem Cell Research & Therapy·Janine ObendorfMandy Laube
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Na RenXin Yu
Feb 25, 2021·Oxidative Medicine and Cellular Longevity·Barbara Sampaio Dias Martins MansanoAndrey Jorge Serra
Aug 24, 2021·Journal of Bioscience and Bioengineering·Yasushi SatoYasuhide Nakayama
Sep 14, 2021·Frontiers in Cardiovascular Medicine·Cai-Yu ZengYuan-Qiang Lu

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