Cardiac chondrosarcoma producing parathyroid hormone-related protein

Circulation Journal : Official Journal of the Japanese Circulation Society
Satoru KaseHisao Ito

Abstract

Chondrosarcoma is a malignant tumor characterized by the formation of cartilage. A case of primary cardiac chondrosarcoma of the left atrium developed in a middle-aged male. The preoperative serum concentrations of C-parathyroid hormone-related protein (PTHrP) and calcium were high (413.2 pmol/L and 12.2 mg/dl, respectively), but normalized after resection of the tumor, which measured 7 x 5 x 3.5 cm. The tumor was histopathologically diagnosed as chondrosarcoma, composed of outer atypical chondroid cells and inner pleomorphic and spindle mesenchymal cells mimicking malignant fibrous histiocytoma. Half of the cartilaginous tumor cells and a few pleomorphic cells showed cytoplasmic immunoreactivity for PTHrP. The tumor is a possible example of the functional pleiotropy of chondrosarcoma.

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Citations

Mar 21, 2008·Seminars in Diagnostic Pathology·Allen Burke
Aug 19, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·S Neragi-MiandoabG J Vlahakes
Feb 9, 2012·Journal of Cardiac Surgery·Guofei ZhangYiming Ni

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