Cardiac computed tomography imaging in familial hypercholesterolaemia: implications for therapy and clinical trials

Current Opinion in Lipidology
Eric J SijbrandsFH CTA Consortium

Abstract

The purpose of the present review is to summarize the potential clinical applications of computed tomographic angiography (CTA) in familial hypercholesterolemia so far and recent advances of CTA research in other high-risk patients. Long-term, aggressively statin-treated, asymptomatic familial hypercholesterolemia patients may still have dramatic coronary artery disease (CAD). A clear association between the presence and the extent of nonobstructive CAD and all-cause mortality was found in the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry. Notably, baseline statin therapy was associated with a significantly lower mortality for individuals with atherosclerotic plaque on CTA, but not for individuals with normal coronary arteries. CTA imaging has made clear that an increased plaque burden can be present even among asymptomatic, long-term aggressively statin-treated familial hypercholesterolemia patients. In the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry, nonobstructive CAD predicted all-cause mortality and statin treatment improved the life span of persons with nonobstructive CAD. Clinical trials with CTA are required to develop ...Continue Reading

References

May 4, 2004·Journal of the American College of Cardiology·Paolo RaggiTracy Q Callister
Jan 31, 2006·European Heart Journal·Leslee J ShawDaniel S Berman
Nov 13, 2008·BMJ : British Medical Journal·Jorie VersmissenEric J G Sijbrands
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Lawrence H YoungUNKNOWN DIAD Investigators
Jun 13, 2009·JACC. Cardiovascular Imaging·Ammar SarwarKhurram Nasir
Apr 29, 2010·JAMA : the Journal of the American Medical Association·Tamar S PolonskyPhilip Greenland
Nov 26, 2010·Circulation·Philip GreenlandUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Jan 15, 2014·International Journal of Cardiology·Gerald F WattsJohn J P Kastelein
Apr 4, 2015·Journal of the American College of Cardiology·Rishi PuriSteven E Nissen
Apr 26, 2015·The American Journal of Medicine·Rikke E MolsBjarne L Nørgaard

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Citations

May 21, 2016·Nature Reviews. Endocrinology·Katrina L EllisGerald F Watts
Jul 19, 2017·European Journal of Preventive Cardiology·Gerald F Watts, Jing Pang
Oct 17, 2018·Current Opinion in Lipidology·Gerald F Watts, Eric S G Stroes
Nov 30, 2016·Platelets·Marie-Cécile ValéraOlivier Lairez
Feb 24, 2016·Journal of Atherosclerosis and Thrombosis·Jing PangGerald F Watts

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Methods Mentioned

BETA
imaging technique

Software Mentioned

CONFIRM

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