Cardiac connexins: genes to nexus

Advances in Cardiology
Heather S DuffyDavid C Spray

Abstract

Gap junctions are formed of at least 20 connexin proteins in mammals and possibly pannexins as well. Of the connexins, at least 5 (Cx30.2, Cx37, Cx40, Cx43 and Cx45) are prominently expressed in the heart and each shows regional and cell type specific expression. Contributions of each of these connexins to heart function has been in many cases illuminated by connexin null mice. The cardiac connexin genes whose genomic organization and transcriptional controls have been studied most thoroughly indicate more complex possibilities for alternate promoter usage than originally thought as well a multiple transcription factor binding sites; presumably, such complexity governs developmental timing and regional connexin expression patterns. The structure of cardiac connexin proteins indicate four primarily alpha-helical transmembrane domains, cytoplasmic amino and carboxyl termini and a cytoplasmic loop, all of which contain some regions of alpha-helix, and extracellular loops that are primarily Beta-structure. A number of proteins that bind to cardiac connexins are known, and more are certain to be discovered, linking the connexin into an intercellular signaling complex, the nexus. Binding sites may either correspond to structured regi...Continue Reading

Citations

Sep 17, 2009·Functional & Integrative Genomics·D A IacobasD C Spray
Dec 20, 2011·Circulation·David W Van NorstrandMichael J Ackerman
Nov 13, 2009·The Journal of Clinical Investigation·Guey-Shin WangThomas A Cooper
Apr 10, 2010·Journal of Biomedicine & Biotechnology·Takahiko ShiinaYasutake Shimizu
Jul 24, 2008·Cell Communication & Adhesion·Jan Sebastian SchulteStefan Dhein
Jun 21, 2015·Cellular and Molecular Life Sciences : CMLS·Merlijn J MeensHeather S Duffy
Jan 5, 2010·Biochemical and Biophysical Research Communications·Dumitru A IacobasGabriel G Haddad
Feb 8, 2011·Journal of Cardiovascular Pharmacology·Filomena G Ottaviano, Karen O Yee
May 11, 2011·Journal of Cellular and Molecular Medicine·Silvia NistriDaniele Bani
May 3, 2013·Journal of Cellular and Molecular Medicine·Jennifer Petsche ConnellJeffrey G Jacot
Apr 21, 2016·PloS One·Zannatul FerdousFrank Christopher Howarth
Jan 24, 2019·Cancers·Pawel Swietach, Stefania Monterisi
Sep 5, 2009·Journal of Molecular and Cellular Cardiology·John A JansenHarold V M van Rijen

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