PMID: 3773509Nov 1, 1986Paper

Cardiac cryosurgery: regional myocardial blood flow of ventricular cryolesions

The Journal of Surgical Research
W L HolmanJ L Cox

Abstract

Cryosurgery is one of three methods introduced recently for the treatment of ventricular tachyarrhythmias. Cryothermic exposure ablates arrhythmogenic ventricular myocardium, and produces a dense fibrous scar with a sharp border to histologically normal tissue. Myocardial blood flow in the region of the cryolesion, however, has not been quantitated. The purpose of this study was to measure regional blood flow within and around the cryolesion in an attempt to identify ischemic zones that might become arrhythmogenic. Left ventricular cryolesions were created in eleven adult dogs. Two weeks later, the animals underwent radioactive tracer microsphere injection for quantitation of regional myocardial blood flow. The fibrotic cryolesion demonstrated a significantly depressed blood flow (0.44 +/- 0.07 ml/min/g) compared to blood flow in control tissue (1.36 +/- 0.12 ml/min/g) (P less than 0.001). A 1-mm strip of myocardium immediately adjacent to the cryolesion, as well as other myocardium surrounding and subjacent to the cryolesion, did not show a significant decrease in regional blood flow. The border between the fibrotic cryolesion and the surrounding myocardium is, therefore, sharply defined not only in terms of histology but also...Continue Reading

References

Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Jan 1, 1983·The American Journal of Cardiology·W L HolmanJ L Cox
Feb 1, 1981·Cryobiology·V C GiampapaA H Aufses

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Citations

Feb 15, 2005·Ultrasound in Medicine & Biology·J KuoO T von Ramm
Aug 13, 1999·Progress in Cardiovascular Diseases·D L LustgartenJ Ruskin
May 1, 1996·Journal of Cardiovascular Electrophysiology·W C HargroveJ M Miller
Nov 1, 1988·The Annals of Thoracic Surgery·J L Cox, M Rosenbloom
Apr 11, 2013·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Faisal H CheemaHarold G Roberts
Nov 14, 1998·The American Journal of Physiology·C W LewisD A Taylor

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