Cardiac death after autologous stem cell transplantation (ASCT) for treatment of systemic sclerosis (SSc): no evidence for cyclophosphamide-induced cardiomyopathy

Bone Marrow Transplantation
O RosenR Arnold

Abstract

In patients with systemic sclerosis (SSc) treatment-related mortality after autologous stem cell transplantation (ASCT) appears to be increased as compared to patients with hematological malignancies. In our phase I/II study on ASCT in autoimmune diseases a patient with SSc died on day 2 after ASCT. Here we report the results of the autopsy which revealed advanced pulmonary and cardiac fibrosis as the most probable cause of death. In spite of detailed technical examination before enrollment, the cardiopulmonary function tests did not reflect the advanced stage of the disease. We conclude that in selected patients with SSc, biopsies should be performed to reduce mortality after ASCT.

Citations

Apr 19, 2002·International Immunopharmacology·Sarah J BinghamPaul Emery
Aug 15, 2006·Annals of the Rheumatic Diseases·M Al-mashalehH Englert
Aug 26, 2004·British Journal of Haematology·Uday Popat, Robert Krance
Feb 3, 2005·British Journal of Haematology·R E HoughN M Wulffraat
Apr 24, 2008·British Journal of Haematology·André TichelliGérard Socié
Aug 11, 2004·Best Practice & Research. Clinical Haematology·Jacob M van Laar, Peter A McSweeney
Apr 2, 2002·Best Practice & Research. Clinical Haematology·A GratwohlUNKNOWN International Stem Cell Project for Autoimmune Diseases
Feb 13, 2002·Bone Marrow Transplantation·J T Beranek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.