Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease

Journal of Nutrition and Metabolism
Annelene GovindsamyMarlon E Cerf

Abstract

Programming with an insult or stimulus during critical developmental life stages shapes metabolic disease through divergent mechanisms. Cardiovascular disease increasingly contributes to global morbidity and mortality, and the heart as an insulin-sensitive organ may become insulin resistant, which manifests as micro- and/or macrovascular complications due to diabetic complications. Cardiogenesis is a sequential process during which the heart develops into a mature organ and is regulated by several cardiac-specific transcription factors. Disrupted cardiac insulin signalling contributes to cardiac insulin resistance. Intrauterine under- or overnutrition alters offspring cardiac structure and function, notably cardiac hypertrophy, systolic and diastolic dysfunction, and hypertension that precede the onset of cardiovascular disease. Optimal intrauterine nutrition and oxygen saturation are required for normal cardiac development in offspring and the maintenance of their cardiovascular physiology.

References

Jul 1, 1992·European Journal of Epidemiology·J Tikkanen, O P Heinonen
May 1, 1997·The American Journal of Physiology·R GagnonB S Richardson
Dec 13, 1997·Pediatric Research·G SimonettaI C McMillen
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
Dec 12, 2001·Molecular and Cellular Endocrinology·T J RoseboomO P Bleker
Jul 13, 2002·American Journal of Medical Genetics·Hans K AkerblomMikael Knip
Sep 28, 2002·Journal of Cardiovascular Pharmacology·Maria do Carmo P FrancoDorothy Nigro
Jan 4, 2003·Hypertension·Imran Y KhanLucilla Poston
Jan 22, 2003·Trends in Cardiovascular Medicine·P Zimmet
Apr 4, 2003·Current Opinion in Genetics & Development·Joseph C Reese
May 31, 2003·Circulation Research·Hiroshi Akazawa, Issei Komuro
Sep 16, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Judith H BurrellEugenie R Lumbers
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsuzakiAkiyoshi Fukamizu
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Guohu LiLubo Zhang
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Taisuke HosakaKaren C Arden
Mar 3, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Laura J WilliamsSonja Rasmussen
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I Y KhanP D Taylor
Sep 24, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Ahmet Alexander Baschat
Mar 19, 2005·The Journal of Physiology·Marie-Claude BattistaMichèle Brochu
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Apr 30, 2005·Trends in Endocrinology and Metabolism : TEM·Andreas BarthelTerry G Unterman
Jun 14, 2005·The International Journal of Biochemistry & Cell Biology·Elizabeth A Woodcock, Scot J Matkovich
Jun 18, 2005·The Journal of Biological Chemistry·Md Ruhul AbidWilliam C Aird
Jul 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paramjit S TappiaNaranjan S Dhalla
Jan 31, 2006·The Proceedings of the Nutrition Society·Simon C Langley-Evans
Jan 31, 2006·Physiology·Abigail L FowdenAlison J Forhead
May 25, 2006·American Journal of Physiology. Endocrinology and Metabolism·Malathi SrinivasanMulchand S Patel
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Jul 11, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·P M Catalano, H M Ehrenberg
Nov 24, 2006·Journal of Applied Physiology·Sonnet S JonkerJ Job Faber

❮ Previous
Next ❯

Citations

Jan 24, 2019·Frontiers in Pharmacology·Zhenzhen LiPeiqing Liu
Sep 7, 2019·International Journal of Molecular Sciences·Andreas BrodehlHendrik Milting
Jun 21, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rolf H SlaatsRobert Passier

❮ Previous
Next ❯

Methods Mentioned

BETA
gene knock-out

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

© 2022 Meta ULC. All rights reserved