The purpose of this investigation was to define the cardiac effects of complement-derived C3a anaphylatoxin, in view of the possibility that cardiac dysfunction may occur as a result of complement activation. Purified human C3a was administered by intracoronary bolus injections into isolated guinea pig hearts. As a function of dose, C3a caused tachycardia, impairment of atrioventricular conduction, left ventricular contractile failure, coronary vasoconstriction, and histamine release. These effects were abolished by cleavage of the COOH-terminal arginine by carboxypeptidase B. The magnitude of C3a-induced tachycardia correlated with the amount of endogenous cardiac histamine released into the coronary effluent. Whereas the tachycardia was markedly reduced by the histamine H2 antagonist cimetidine, the contractile failure and the coronary vasoconstriction caused by C3a were antagonized by the leukotriene antagonist FPL 55712 and by the cyclooxygenase inhibitor indomethacin, respectively. This suggests that histamine, leukotrienes, and vasoactive prostanoates may mediate the various cardiac effects of C3a. Our findings indicate that C3a anaphylatoxin has marked cardiac effects at concentrations that are likely to be attained with...Continue Reading
The heart as a target organ in systemic allergic reactions: comparison of cardiac analphylaxis in vivo and in vitro
Complement profiles in monkeys subjected to aggregate (immune complex) anaphylaxis, and following injection of soluble and particulate polysaccharides
Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine
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The demonstration of histamine release in clinical conditions: a review of past and present assay procedures
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The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo
The cardiac and renal effects of the complement fragment C5a des Arg are partly mediated by the release of histamine and arachidonic acid metabolites
Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts
Activation of complement by tissue plasminogen activator, but not acute cerebral ischemia, in a rabbit model of thromboembolic stroke
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Coronary trapping of a complement activation product (C3a des-Arg) during myocardial reperfusion in open-heart surgery
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Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques
Complement activation during major surgery: the effect of extracorporeal circuits and high-dose aprotinin
Altered concentrations of terminal complement complexes, anaphylatoxins, and leukotrienes in the coronary sinus during cardiopulmonary bypass
Alterations in myocardial systolic and diastolic function in patients with active systemic lupus erythematosus
Cardiac output in patients with acute lower limb ischaemia of presumed embolic origin--a predictor of severity and outcome?
Perioperative effect of methylprednisolone given during lung surgery on plasma concentrations of C3a and C5a
C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism
Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart. Evidence that complement activation is required for neutrophil-mediated reperfusion injury
Thromboxane A2 and peptidoleukotrienes contribute to the myocardial ischemia and contractile dysfunction in response to intracoronary infusion of complement C5a in pigs
Soluble complement receptor-1 protects heart, lung, and cardiac myofilament function from cardiopulmonary bypass damage
Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia
Isolated hyperthermic liver perfusion with cytostatic-containing perfusate activates the complement cascade
Complement activation by extracorporeal circulation: effects of precoating a membrane oxygenator circuit with human whole blood
Complement Activation and Organ Damage After Trauma-Differential Immune Response Based on Surgical Treatment Strategy.
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
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