Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.

Cardiovascular Research
Carlo Gabriele TocchettiThomas Thum

Abstract

In western countries, cardiovascular (CV) disease and cancer are the leading causes of death in the ageing population. Recent epidemiological data suggest that cancer is more frequent in patients with prevalent or incident CV disease, in particular, heart failure (HF). Indeed, there is a tight link in terms of shared risk factors and mechanisms between HF and cancer. HF induced by anticancer therapies has been extensively studied, primarily focusing on the toxic effects that anti-tumour treatments exert on cardiomyocytes. In this Cardio-Oncology update, members of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart discuss novel evidence interconnecting cardiac dysfunction and cancer via pathways in which cardiomyocytes may be involved but are not central. In particular, the multiple roles of cardiac stromal cells (endothelial cells and fibroblasts) and inflammatory cells are highlighted. Also, the gut microbiota is depicted as a new player at the crossroads between HF and cancer. Finally, the role of non-coding RNAs in Cardio-Oncology is also addressed. All these insights are expected to fuel additional research efforts in the field of Cardio-Oncology.

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Citations

Jan 9, 2021·Current Oncology Reports·Flora PirozziValentina Mercurio
Nov 29, 2020·European Journal of Heart Failure·Markus S AnkerStefan D Anker
Mar 19, 2021·Journal of Cachexia, Sarcopenia and Muscle·Markus S AnkerStefan D Anker
Apr 13, 2021·Journal of Advanced Research·Mohammed SafiJiwei Liu
May 15, 2021·Frontiers in Physiology·Daniela SorrientoGuido Iaccarino
Jun 29, 2021·Current Heart Failure Reports·Alessandra CuomoFlora Pirozzi

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