Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome

European Journal of Endocrinology
A M PereiraRichard A Feelders

Abstract

In patients with active Cushing's syndrome (CS), cardiac structural and functional changes have been described in a limited number of patients. It is unknown whether these changes reverse after successful treatment. We therefore evaluated the changes in cardiac structure and dysfunction after successful treatment of CS, using more sensitive echocardiographic parameters (based on two-dimensional strain imaging) to detect subtle changes in cardiac structure and function. In a prospective study design, we studied 15 consecutive CS patients and 30 controls (matched for age, sex, body surface area, hypertension, and left ventricular (LV) systolic function). Multidirectional LV strain was evaluated by two-dimensional speckle tracking strain imaging. Systolic (radial thickening, and circumferential and longitudinal shortening) and diastolic (longitudinal strain rate at the isovolumetric relaxation time (SR(IVRT))) parameters were measured. At baseline, CS patients had similar LV diameters but had significantly more LV hypertrophy and impaired LV diastolic function, compared to controls. In addition, CS patients showed impaired LV shortening in the circumferential (-16.5+/-3.5 vs -19.7+/-3.4%, P=0.013) and longitudinal (-15.9+/-1.9 vs ...Continue Reading

Citations

Nov 8, 2011·Basic Research in Cardiology·Diederik W D KusterDirk J Duncker
Jun 26, 2013·European Heart Journal Cardiovascular Imaging·Cornelis J RoosVictoria Delgado
Oct 21, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Kan N HorD Woodrow Benson
Oct 19, 2011·European Journal of Endocrinology·Kai Hang YiuAlberto M Pereira
Aug 30, 2013·European Journal of Endocrinology·Oskar Ragnarsson, Gudmundur Johannsson
Apr 5, 2014·Indian Journal of Endocrinology and Metabolism·Ariacherry C AmminiSudhir Tripathi
Jun 26, 2012·European Journal of Endocrinology·R A FeeldersA M Pereira
Jun 2, 2012·Journal of Endocrinological Investigation·G ArnaldiM Boscaro
Jul 18, 2014·Endocrinology, Diabetes & Metabolism Case Reports·Hiroaki Iwasaki
Apr 25, 2012·Pituitary·Elena ValassiSusan M Webb
Aug 2, 2012·Endocrine·Francesco FalloFrancesco Tona
May 7, 2015·Acta Clinica Belgica·Masoud RahmanianR N Moghadam
Jun 11, 2015·European Journal of Endocrinology·Francesco Ferraù, Márta Korbonits
Mar 1, 2015·Pituitary·S T SharmaR A Feelders
Jan 13, 2015·Pituitary·Georgia NtaliNiki Karavitaki
Jun 4, 2016·Nature Reviews. Endocrinology·Johannes A Romijn
Feb 19, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Robert J Deegan, William R Furman
Dec 30, 2017·Indian Journal of Endocrinology and Metabolism·Aditya John BinuThomas Vizhalil Paul
Mar 8, 2018·European Journal of Endocrinology·Emilia SbardellaAndrea M Isidori
Mar 1, 2012·Echocardiography·Tomasz Miszalski-JamkaJacek Musiał
Dec 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Sean H P P RoerinkAd R M M Hermus
May 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Guido Di DalmaziUberto Pagotto
May 22, 2020·The Journal of Clinical Endocrinology and Metabolism·Eleni PapakokkinouOskar Ragnarsson
Jun 13, 2015·Endocrine Reviews·Rosario PivonelloAnnamaria Colao
Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Christian AdolfMartin Reincke
Feb 18, 2017·Endocrine·D A Vassiliadi, S Tsagarakis
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·María-José BarahonaSusan M Webb
Mar 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Olaf M DekkersHenrik Toft Sørensen
Jul 28, 2020·International Journal of Molecular Sciences·Luigi PetramalaClaudio Letizia
Aug 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Peter WolfPeter Kamenický
Nov 7, 2020·Current Pharmaceutical Design·Apostolos I GogakosZoe A Efstathiadou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.