Cardiac Effects of Antiretroviral-Naïve versus Antiretroviral-Exposed HIV Infection in Children

PloS One
Nikmah S IdrisCuno S P M Uiterwaal

Abstract

Cardiac involvement in HIV infected children has been frequently reported, but whether this is due to HIV infection itself or to antiretroviral treatment (ART) is unknown. This cross sectional study involved 114 vertically-acquired HIV-infected (56 ART-naive, 58 ART-exposed) and 51 healthy children in Jakarta, Indonesia. Echocardiography was performed to measure dimensions of the left ventricle (LV) and systolic functions. We applied general linear modeling to evaluate the associations between HIV infection/treatment status and cardiac parameters with further adjustment for potential confounders or explanatory variables. Findings are presented as (adjusted) mean differences between each of the two HIV groups and healthy children, with 95% confidence intervals and p values. Compared to healthy children, ART-naïve HIV-infected children did not show significant differences in age-and-height adjusted cardiac dimensions apart from larger LV internal diameter (difference 2.0 mm, 95%CI 0.2 to 3.7), whereas ART exposed HIV infection showed thicker LV posterior walls (difference = 1.1 mm, 95%CI 0.5 to 1.6), larger LV internal diameter (difference = 1.7 mm, 95%CI 0.2 to 3.2) and higher LV mass (difference = 14.0 g, 7.4 to 20.5). With res...Continue Reading

References

Jun 9, 1993·JAMA : the Journal of the American Medical Association·L M LuginbuhlS E Lipshultz
Jul 25, 2000·Circulation·B H Lorell, B A Carabello
Mar 2, 2002·The Lancet Infectious Diseases·G BarbaroS E Lipshultz
Sep 21, 2002·Lancet·Steven E LipshultzUNKNOWN Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P(2)C(2) HIV) Study Group
May 24, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Debra L KearneyUNKNOWN Pediatric Pulmonary and Cardiovascular Complication of Vertically Transmitted HIV Infected (P2C2 HIV) Study Group, National
Jul 23, 2003·AIDS·Peter F Currie, Nicholas A Boon
May 1, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Amy SimsCraig Sable
Jan 7, 2015·AIDS·Steven E LipshultzUNKNOWN Pediatric HIVAIDS Cohort Study (PHACS)

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Citations

Nov 26, 2016·European Journal of Preventive Cardiology·Justin S KuilderCuno Spm Uiterwaal
Mar 31, 2019·Journal of Clinical Medicine·Birkneh Tilahun TadesseEleni Aklillu
Aug 12, 2017·Current Opinion in HIV and AIDS·Andrew W McCraryGerald S Bloomfield
May 16, 2020·The Pediatric Infectious Disease Journal·Nathália Gaspar ValliloGabriela Nunes Leal

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Methods Mentioned

BETA
PCR

Software Mentioned

RStudio
SPSS

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