Cardiac Effects of Highly Active Antiretroviral Therapy in Perinatally HIV-Infected Children: The CHAART-2 Study

Journal of the American College of Cardiology
Steven E LipshultzCHAART-2 Investigator Group

Abstract

Before the introduction of highly active antiretroviral therapy (HAART), cardiac mortality and morbidity were common in HIV-infected children. This study sought to identify long-term cardiovascular effects of HAART in HIV-infected children. The CHAART-2 (HAART-Associated Cardiotoxicity in HIV-Infected Children) study prospectively compared 148 echocardiograms from 74 HAART-exposed children to 860 echocardiograms from 140 HAART-unexposed but HIV-infected children from the Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) study. Both studies used similar protocol, centralized echocardiographic interpretation, and measures expressed as z-scores referenced to healthy controls. Associations between HAART exposure and echocardiographic measures were evaluated using generalized estimating equations. Comparing the HAART-exposed and HAART-unexposed groups, any HAART exposure was positively associated with left ventricular (LV) fractional shortening (z-score for difference = 1.07; p = 0.02) and HAART exposure duration (z-score difference per year = 0.17; p = 0.003. LV mass was negatively associated with any HAART exposure (z-score difference = -0.64; p = 0.01) as was septal thickness (z-score differen...Continue Reading

References

Mar 29, 2001·American Heart Journal·W W LaiUNKNOWN P2C2 HIV Study Group, National Heart, Lung, and Blood Institute
Sep 21, 2002·Lancet·Steven E LipshultzUNKNOWN Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P(2)C(2) HIV) Study Group
May 14, 2003·Journal of the American College of Cardiology·Inas Al-AttarSteven E Lipshultz
May 24, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Debra L KearneyUNKNOWN Pediatric Pulmonary and Cardiovascular Complication of Vertically Transmitted HIV Infected (P2C2 HIV) Study Group, National
Jul 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·A R Perez-AtaydeUNKNOWN P2C2 HIV Study Group
Sep 17, 2004·Cardiovascular Toxicology·Jill E LavigneUNKNOWN CHAART Study Group
Nov 24, 2004·Journal of Applied Physiology·Thierry Sluysmans, Steven D Colan
Sep 20, 2005·American Heart Journal·Stacy D FisherUNKNOWN Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group
Jul 12, 2012·AIDS·Kunjal PatelUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials 219219C Study Team
Dec 25, 2013·Circulation·Kunjal PatelUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS)

❮ Previous
Next ❯

Citations

Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Fabio MarsicoPasquale Perrone Filardi
Oct 18, 2019·JCI Insight·Daniel BraysonCatherine M Shanahan
Dec 10, 2020·Arquivos brasileiros de cardiologia·Samira Saady MorhyMarcelo Luiz Campos Vieira
Feb 24, 2021·Heart Failure Reviews·Harry ChoiHani Jneid
Aug 25, 2020·Progress in Pediatric Cardiology·Paul Barach, Steven E Lipshultz
Oct 16, 2021·Current HIV/AIDS Reports·Sahera Dirajlal-Fargo, Grace A McComsey
Oct 28, 2017·Journal of the American College of Cardiology·Joseph W Rossano, Kimberly Y Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.