Cardiac effects of isoliquiritigenin

European Journal of Pharmacology
J W Wegener, H Nawrath

Abstract

The effects of isoliquiritigenin on force of contraction (Fc), L-type Ca2+ current (I(Ca)) and intracellular Ca2+ concentration ([Ca2+]i) were investigated in rat ventricular heart muscle. Isoliquiritigenin increased Fc and I(Ca) and, after longer exposure times, resting tension and [Ca2+]i. The effect of isoliquiritigenin (100 microM) on I(Ca) was diminished by Rp-cAMPS (30 microM). 1H-[1,2,4]oxa- diazolo[4,3-a]quinoxalin-1-one (50 microM) did not influence the effects of isoliquiritigenin on Fc and I(Ca). The positive inotropic effects of isoprenaline and forskolin, but not of 3-isobutyl-1-methylxanthine, were potentiated by isoliquiritigenin (100 microM). In the presence of milrinone (10 microM), no further effects of isoliquiritigenin (100 microM) on Fc and I(Ca) were observed. It is suggested that the increase in Fc and I(Ca) by isoliquiritigenin is due to an accumulation of cyclic AMP. These effects are probably unrelated to an effect of the drug on soluble guanylyl cyclase, as reported for smooth muscle, but rather due to a direct inhibition of phosphodiesterase III activity.

References

Dec 18, 1992·Science·J S StamlerJ Loscalzo
Aug 1, 1991·Circulation Research·N Tohse, N Sperelakis
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F MéryR Fischmeister
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·L J Ignarro
Jun 1, 1987·The Journal of Physiology·R Fischmeister, H C Hartzell
Jan 1, 1988·Progress in Biophysics and Molecular Biology·H C Hartzell
Apr 1, 1989·Pflügers Archiv : European journal of physiology·R C LeviR Fischmeister
Aug 15, 1989·Biochemical and Biophysical Research Communications·E L RuggG Cramb
Aug 17, 1981·Biochimica Et Biophysica Acta·T M Lincoln, S L Keely
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Sep 1, 1995·Progress in Cardiovascular Diseases·J M Hare, W S Colucci
Apr 1, 1995·Zoological Science·R T MacFarland
Sep 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·J W Wegener, H Nawrath
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
Dec 15, 1995·The Journal of Physiology·S D KohK M Sanders

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Citations

May 25, 2002·British Journal of Pharmacology·J W WegenerH Nawrath
Dec 1, 1977·Il Torace·M Anzalone
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Sep 4, 2009·Journal of Hematology & Oncology·Subhash PadhyeFazlul H Sarkar
Dec 23, 2008·Journal of Pharmacological Sciences·Chisato NoguchiJunko Kimura
Dec 28, 2010·International Immunopharmacology·Vivek R YadavBharat B Aggarwal
May 9, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Supaluk PrachayasittikulVirapong Prachayasittikul
Mar 16, 2002·International Journal of Impotence Research·J D BrioniJ P Sullivan
Jul 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yulong ZhangXiaobo Li
Feb 26, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan GaoMing-Jun Zhu
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