Cardiac effects of propofol and its interaction with autonomic nervous system in isolated, cross-circulated canine atria

Journal of Anesthesia
Y NagashimaS Chiba

Abstract

The effects of propofol on sinoatrial pacemaker activity and myocardial contractility and its interaction with the autonomic nervous system were investigated in isolated, cross-circulated right atrial canine preparations. An isolated right atrial preparation was perfused with heparinized arterial blood from an anesthetized support dog and changes in atrial rate and atrial contractile force were recorded. Propofol (30-1000 microg) and thiopental (30-1000 microg), injected into the sinus node artery of the isolated atrium, induced dose-dependent decreases in atrial rate and contractile force. The negative chronotropic and inotropic effects of propofol were greater than those of thiopental. The propofol-induced negative chronotropic and inotropic responses were not inhibited by atropine. Propofol had no effects on the cardiac responses to acetylcholine, norepinephrine, and the intracardiac parasympathetic nerve stimulation which activates ganglionic nicotinic acetylcholine receptors. These results indicate that: (a) propofol directly depresses sinoatrial pacemaker activity and myocardial contractility, (b) the negative chronotropic and inotropic effects of propofol do not involve activation of muscarinic receptors, and (c) propofo...Continue Reading

Citations

May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Radoslaw OwczukMaria Wujtewicz
Dec 1, 2015·American Journal of Veterinary Research·Rachel A ReedThomas J Doherty
Jan 18, 2012·Veterinary Anaesthesia and Analgesia·Rodrigo MannarinoVanessa B Castro
Jan 17, 2015·Pacing and Clinical Electrophysiology : PACE·T Scott WallMohamed H Hamdan
Oct 5, 2018·Journal of Clinical Monitoring and Computing·Maddalena ArdissinoMarcela Vizcaychipi
Jun 19, 2017·Veterinary Anaesthesia and Analgesia·Carrie A DavisThomas J Doherty

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