Cardiac effects of sodium selenite.

Cardiology
D M AviadoP M Lish

Abstract

The classical idea that selenium is toxic to the heart at levels higher than available in a balanced diet is not supported by experimental work. In mice, treatment with sodium selenite increased the LD50 of ouabain and 2,4-dinitrophenol, and increased the tolerance to nitrogen inhalation. Although sodium selenite had no effect on the dog heart with circulation intact, there was a reduction in coronary vascular resistance in the heart-lung preparation. In the isolated ventricular segment perfused with blood, the administration of sodium selenite caused a positive inotropic effect which appeared even after blockade of beta-adrenergic receptors and in segments perfused with a Krebs-bicarbonate solution that was deficient in oxygen. These results cannot be explained merely as the correction of a selenium deficiency but rather as a positive influence of sodium selenite on the heart that has been acutely stressed by oxygen lack, ouabain, or 2,4-dinitrophenol.

Citations

Dec 9, 1998·Biological Trace Element Research·E Demirel-YilmazB Turan
Jul 24, 1998·Biological Trace Element Research·B TuranE Demirel
Apr 9, 1998·Biological Trace Element Research·J KadrabováE Ginter
Feb 1, 1990·Biological Trace Element Research·O Oster, W Prellwitz
Mar 1, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·O OsterT Meinertz
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