Cardiac electrical dyssynchrony is accurately detected by noninvasive electrocardiographic imaging

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Laura R BearRémi Dubois

Abstract

Poor identification of electrical dyssynchrony is postulated to be a major factor contributing to the low success rate for cardiac resynchronization therapy. The purpose of this study was to evaluate the sensitivity of body surface mapping and electrocardiographic imaging (ECGi) to detect electrical dyssynchrony noninvasively. Langendorff-perfused pig hearts (n = 11) were suspended in a human torso-shaped tank, with left bundle branch block (LBBB) induced through ablation. Recordings were taken simultaneously from a 108-electrode epicardial sock and 128 electrodes embedded in the tank surface during sinus rhythm and ventricular pacing. Computed tomography provided electrode and heart positions in the tank. Epicardial unipolar electrograms were reconstructed from torso potentials using ECGi. Dyssynchrony markers from torso potentials (eg, QRS duration) or ECGi (total activation time, interventricular delay [D-LR], and intraventricular markers) were correlated with those recorded from the sock. LBBB was induced (n = 8), and sock-derived activation maps demonstrated interventricular dyssynchrony (D-LR and total activation time) in all cases (P < .05) and intraventricular dyssynchrony for complete LBBB (P < .05) compared to normal ...Continue Reading

Citations

May 18, 2018·Journal of Cardiovascular Electrophysiology·Miguel Rodrigo, Sanjiv M Narayan
Apr 3, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Andrés Ricardo Pérez-RieraKjell Nikus
Jan 15, 2020·Circulation. Arrhythmia and Electrophysiology·Adam J GrahamPier D Lambiase
Mar 28, 2019·Frontiers in Physiology·Danila PotyagayloDmitry Lebedev
Apr 27, 2019·Frontiers in Physiology·Erick Andres Perez AldayMichael A Colman
Dec 28, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Uyên Châu NguyênKevin Vernooy
Dec 7, 2018·Medical & Biological Engineering & Computing·Önder Nazım OnakGerhard Wilhelm Weber
Dec 22, 2020·Journal of Cardiovascular Electrophysiology·Ahran D ArnoldZachary I Whinnett
Aug 12, 2019·Cardiac Electrophysiology Clinics·Ghassen ChenitiMichel Haissaguerre
Apr 22, 2021·Journal of the American Heart Association·Laura R BearRémi Dubois
Jul 28, 2021·Computers in Biology and Medicine·Ali S RababahDewar D Finlay
Aug 21, 2021·Journal of Electrocardiology·Mark K ElliottChristopher A Rinaldi
Aug 18, 2021·Arrhythmia & Electrophysiology Review·Ksenia SedovaJosef Kautzner

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