May 1, 1981

Cardiac electrophysiologic effects of quinidine and propranolol isomers in anesthetized dogs: concentration-response relationships

Journal of Cardiovascular Pharmacology
P JaillonG Cheymol

Abstract

Electrophysiological properties of quinidine and the two isomers of propranolol were compared in pentobarbital-anesthetized dogs using His bundle recordings and programmed stimulation in order to differentiate the effects resulting from beta-blockade from those related to nonspecific membrane-stabilizing effects. Quinidine in the plasma concentration range of 2.7-20 microM/liter resulted in concentration-dependent increases in atrionodal and His-Purkinje system conduction times and in the atrial effective refractory period. Quinidine did not produce any significant concentration-dependent change in atrioventricular (AV) nodal and ventricular refractory periods, sinus node automaticity, or QTc interval duration. Propranolol isomers in concentration range of 0.03-0.85 microM/liter produced a concentration-dependent increase in atrionodal conduction time but exerted no significant effect on His-Purkinje conduction time, QTc duration, or ventricular refractory period. Both isomers increased the atrial effective refractory period, but with slopes of concentration-response regression lines which were significantly different from those of quinidine. Only l-propranolol produced concentration-dependent increases in AV nodal refractory p...Continue Reading

  • References
  • Citations3

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations3

Citations

Mentioned in this Paper

Sinoatrial Node
Molecular Stereochemistry
Quinidex
Exertion
Refractory Period, Electrophysiological
Anesthesia Procedures
Refractory Period
Quinidine Measurement
Cardiac Conduction System
Structure of Atrioventricular Node

About this Paper

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.