PMID: 8950420Dec 1, 1996Paper

Cardiac electrophysiologic measurements in dogs before and after intravenous administration of atropine and propranolol

American Journal of Veterinary Research
K N WrightJ M Bright

Abstract

To assess baseline cardiac electrophysiologic (EP) measurements in dogs undergoing a clinically used anesthetic protocol, and to study the effects of i.v. administered atropine and propranolol on these EP variables. 15 adult dogs with cardiac function within reference ranges, as assessed by physical examination, electrocardiography, and echocardiography. 13 cardiac EP variables were measured in isofluorane-anesthetized dogs before and after i.v. administration of atropine and propranolol. Multipolar electrode catheters were positioned against the endocardium of the dorsal portion of the right atrium, His bundle region, and right ventricular apex. Incremental pacing and pacing-extrastimulus techniques were used to obtain EP measurements of the sinoatrial node, atrioventricular node, and atrial and ventricular myocardia in the control state and after i.v. administration of 0.04 mg of atropine and 0.2 mg of propranolol/kg of body weight. Only the atrial effective refractory period changed significantly after muscarinic and beta-adrenergic receptor antagonism. Marked individual variation in response to these agents, however, was apparent. Two dogs had substantial decreases in sinoatrial and/or atrioventricular nodal measurements, a...Continue Reading

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