Cardiac expression of polysialylated NCAM in the chicken embryo: correlation with the ventricular conduction system

Developmental Dynamics : an Official Publication of the American Association of Anatomists
M WatanabeH Fallah-Najmabadi

Abstract

The neural cell adhesion molecule (NCAM) and its polysialic acid moeity (PSA) affect cellular interactions during the development of the nervous system and skeletal muscle. NCAM has also been identified in the embryonic heart of various species including humans. However, knowledge regarding the role of NCAM and its function-modulating PSA in cardiogenesis is limited. The distribution of NCAM and its PSA in the ventricular myocardium of chicken embryos was determined by indirect immunofluorescence staining. The NCAM polypeptide was found throughout the cardiac myocardium. In contrast PSA was located in discrete regions in stage 20 to 44 embryos (during and after septation). Myocardium at the subendocardial regions of the atrioventricular canal and ventricular trabeculae were PSA positive by stage 20. At later stages, transverse sections of the postseptation heart just below the level of the atrioventricular interface revealed a PSA-positive bundle of myocardium in the septum. This bundle was continuous with two branches at a more apical level which in turn were continuous with the PSA-positive subendocardial myocardium lining the left and right ventricles. This pattern of PSA in the myocardium was similar to that of the ventricu...Continue Reading

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Related Concepts

Structure of Purkinje Fibers
Immunofluorescence Assay
Myocardium
Myocardial Stunning
Atrioventricular CANAL Defect
Chick Embryo
Salivary Gland Pleomorphic Adenoma
Heart
Sialic Acids
Cell Adhesion Molecules, Neuronal

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