Cardiac failure 30 years after treatment containing anthracycline for childhood acute lymphoblastic leukemia.

Journal of Pediatric Hematology/oncology
John M GoldbergSteven E Lipshultz

Abstract

In 1977, a 5-year-old girl diagnosed with acute lymphoblastic leukemia was treated on Dana-Farber Cancer Institute Childhood Acute Lymphoblastic Leukemia Protocol 77-01, receiving a cumulative doxorubicin dose of 465 mg/m(2), cranial radiation, and other drugs. After being in continuous complete remission for 34 months, she developed heart failure and was treated with digoxin and furosemide. At 16 years of age, she was diagnosed and treated for dilated cardiomyopathy. Over the years, she continued to have bouts of heart failure, which became less responsive to treatment. At 36 years of age, she received a heart transplant. Six months later, she stopped taking her medications and suffered a sudden cardiac death.

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Citations

Jul 5, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Steven E Lipshultz
Jun 28, 2015·Cancer Chemotherapy and Pharmacology·Pascal ChastagnerNicolas André
Aug 19, 2014·International Journal of Cardiology·Salvatore Patanè
Oct 2, 2013·Circulation·Steven E LipshultzUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
Sep 20, 2012·Circulation. Cardiovascular Imaging·Steven E LipshultzJames D Wilkinson
Jul 10, 2014·Pediatric Surgery International·M A Mushfiqur RahmanTahmina Banu
May 11, 2021·Frontiers in Cardiovascular Medicine·Caroline LozahicHardip Sandhu

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