Cardiac findings in routine fetal autopsies: more than meets the eye?

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Carla RamalhoNuno Montenegro

Abstract

The main objective of this study was to evaluate the spectrum of cardiac anomalies found in routinely performed fetal autopsies and to establish the correlation between prenatal and postmortem diagnosis. A retrospective study of fetal autopsies was performed. Cases with cardiac anomalies were analyzed. Seven main categories were established and each case was assigned to a single group. Cardiac defects were also classified as isolated or with associated anomalies. In the cases with prenatal diagnosis, we performed a correlation between prenatal and postmortem findings. Abnormal cardiac findings were identified in 99 fetuses (13.6%). The two most common categories were septal defects and complex anomalies, each occurring in 21 fetuses (21.2%). Sixty-seven (67.7%) had associated anomalies. Septal anomalies were more frequent in cases with associated anomalies (p=0.012). Prenatal diagnosis had been performed in 50 cases. There was complete agreement between prenatal and postmortem diagnosis in 36 cases (72%), and major agreement with additional information in ten (20%). When the echocardiogram was not performed by a specialist, the number of cases classified with complete disagreement was higher (33.3% vs 2.4%) (p=0.002). The high ...Continue Reading

References

Oct 1, 1978·The American Journal of Cardiology·J I Hoffman, R Christianson
Jul 1, 1991·British Journal of Obstetrics and Gynaecology·J S Wigglesworth
Feb 1, 1987·Journal of Clinical Pathology·H J Porter, J W Keeling
Jul 1, 1985·International Journal of Cardiology·M SamánekD Benesová
Mar 1, 1971·Circulation·S C MitchellH W Berendes
Jun 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E TegnanderD T Linker
May 1, 1994·Journal of the American College of Cardiology·L D AllanN L Fagg
Nov 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M A RusticoG Mandruzzato
Mar 17, 1997·American Journal of Medical Genetics·J HyettK Nicolaides
Dec 31, 1997·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J A CopelC S Kleinman
Sep 22, 1998·Prenatal Diagnosis·E HafnerK Philipp
Dec 8, 1998·American Journal of Medical Genetics·S B FreemanD M Saker
Mar 18, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C V IsaksenS H Torp
Aug 24, 1999·American Journal of Obstetrics and Gynecology·H GrandjeanS Levi
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E GarneUNKNOWN Euroscan Group
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Meyer-WittkopfG Sholler
Sep 29, 2001·Obstetrics and Gynecology·K LeeR L Mittendorf
Dec 10, 2003·BMJ : British Medical Journal·P A BoydP F Chamberlain
Jun 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Wanda C Miller-Hance, Theresa A Tacy
Jul 31, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Bettina F CuneoHaim Elrad
Feb 4, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E TegnanderS H Eik-Nes
Aug 8, 2006·American Journal of Clinical Pathology·John G ArchieRobert Roger Lebel
Dec 26, 2006·Acta Paediatrica·Annamari NikkiläBengt Källén
Aug 31, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lorenzo D BottoUNKNOWN National Birth Defects Prevention Study
Aug 30, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Elena K Grant, Margaret J Evans
Apr 8, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M S SongL K Hornberger
Apr 23, 2010·European Journal of Pediatrics·Michel Emile WeijermanReinoud J B J Gemke
Mar 2, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R MograL D Allan
Apr 1, 2011·Journal of Clinical Pathology·Carla RamalhoNuno Montenegro

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Citations

Oct 2, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C StruksnaesC Vogt
Jan 12, 2019·Fetal and Pediatric Pathology·Mana Taweevisit, Paul Thorner
Aug 29, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Rebekka LytzenLars Søndergaard
Jul 26, 2017·Der Pathologe·J AndruszkowF Erlmeier
Nov 13, 2019·Fetal and Pediatric Pathology·Mariana Rei, Carla Ramalho
Nov 20, 2020·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Sakthisankari ShanmugasundaramUmamaheswari Gurusamy

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