PMID: 1540062Mar 1, 1992Paper

Cardiac function and myocardial performance of 24-hour-preserved asphyxiated canine hearts

The Annals of Thoracic Surgery
R ShirakuraY Kawashima

Abstract

A method of 24-hour storage of asphyxiated canine hearts for orthotopic cardiac transplantation was studied to expand the geographical size of the donor pool. Left ventricular function of asphyxiated hearts preserved for 24 hours (group 1, n = 8) was compared with that of hearts donated on-site (group 2, n = 5). Group 1 donors were pretreated with verapamil hydrochloride, propranolol hydrochloride, and prostacyclin. The donor hearts were perfused with warm blood cardioplegia in situ after 10 minutes of asphyxiation and then perfused with cold crystalloid cardioplegia for 2 hours. The hearts were excised and stored in ice-cold University of Wisconsin solution for 22 hours. At orthotopic transplantation, coronary perfusion with warm blood cardioplegia was performed before the graft aorta was unclamped. Conventional cardiac variables (eg, cardiac output and maximum rate of rise of left ventricular pressure), myocardial performance, and diastolic compliance of grafted hearts were assessed 1 hour after weaning from bypass. All recipients in both groups were easily weaned from cardiopulmonary bypass without inotropic agents, and there were no significant differences in cardiac variables between the two groups. These results strongly ...Continue Reading

Citations

Jan 24, 2007·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Gentaro KatoShunji Sano
Feb 24, 2001·The Annals of Thoracic Surgery·K SuehiroS Sano
Jun 1, 1997·The Annals of Thoracic Surgery·J T CopeC G Tribble
Nov 15, 2002·Transplantation Proceedings·N FukushimaH Matsuda
Mar 15, 2000·Transplantation Proceedings·N FukushimaH Matsuda
Nov 14, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Makoto MohriShunji Sano
May 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Yasuhiro KotaniShunji Sano
Dec 1, 1994·The Annals of Thoracic Surgery·N FukushimaH Matsuda
Nov 1, 1996·The Annals of Thoracic Surgery·J T CopeC G Tribble
Apr 15, 2003·Cardiology in the Young·Hideki Uemura
Mar 1, 2018·Frontiers in Cardiovascular Medicine·Christopher W WhiteDarren H Freed
Apr 19, 2019·Circulation. Heart Failure·Petra NiederbergerSarah L Longnus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.