Cardiac function during mild hypothermia in pigs: increased inotropy at the expense of diastolic dysfunction

Acta Physiologica
H PostB Pieske

Abstract

The induction of mild hypothermia (MH; 33 degrees C) has become the guideline therapy to attenuate hypoxic brain injury after out-of-hospital cardiopulmonary resuscitation. While MH exerts a positive inotropic effect in vitro, MH reduces cardiac output in vivo and is thus discussed critically when severe cardiac dysfunction is present in patients. We thus assessed the effect of MH on the function of the normal heart in an in vivo model closely mimicking the clinical setting. Ten anaesthetized, female human-sized pigs were acutely catheterized for measurement of pressure-volume loops (conductance catheter), cardiac output (Swan-Ganz catheter) and for vena cava inferior occlusion. Controlled MH (from 37 to 33 degrees C) was induced by a vena cava inferior cooling catheter. With MH, heart rate (HR) and whole body oxygen consumption decreased, while lactate levels remained normal. Cardiac output, left ventricular (LV) volumes, peak systolic and end-diastolic pressure and dP/dt(max) did not change significantly. Changes in dP/dt(min) and the time constant of isovolumetric relaxation demonstrated impaired active relaxation. In addition, MH prolonged the systolic and shortened the diastolic time interval. Pressure-volume analysis reve...Continue Reading

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Citations

Jan 1, 2011·Therapeutic Hypothermia and Temperature Management·David Erlinge
Dec 2, 2011·Cardiovascular Research·Renaud TissierAlain Berdeaux
Jan 1, 2013·Journal of Medical Case Reports·Takanao MineHiroji Miyake
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Jun 1, 2021·Journal of Cellular and Molecular Medicine·Zhuyun QinHaitao Zhang

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