Cardiac function in hearts isolated from a rat model deficient in mast cells

American Journal of Physiology. Heart and Circulatory Physiology
Richard H KennedyJacob Joseph

Abstract

Several studies have examined the role of mast cells in the myocardial response to injury such as that caused by hypertension and ischemia-reperfusion. However, little is known about the influence of mast cells on normal myocardial structure and function. The present experiments examined cardiac function in Langendorff-perfused hearts isolated from 6- and 9-mo-old male mast cell-deficient (Ws/Ws) and mast cell-competent rats. A fluid-filled balloon catheter was used to measure left ventricular diastolic and systolic function at increasing preload volumes. At 6 mo of age, mast cell-deficient rats showed a slight cardiac hypertrophy (as monitored by heart weight and heart weight-to-body weight ratio) but no significant change in maximum observed systolic or diastolic function. In contrast, at 9 mo of age, the mast cell-deficient group showed no signs of hypertrophy but displayed a diastolic dysfunction characterized by decreased compliance without a significant decline in maximum observed basal -dP/dtmax. There were no significant differences in maximum observed values for measures of systolic function (developed pressure and +dP/dtmax). In summary, the results of this study in adult rats suggest that mast cells influence cardiac...Continue Reading

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Citations

Oct 13, 2006·Antioxidants & Redox Signaling·Nikolaos G Frangogiannis
Apr 7, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Heather Francis, Cynthia J Meininger
Dec 14, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Qing-Yong ZhangHung-Fat Tse
Jan 24, 2007·Hypertension·Christian F Deschepper, Bastien Llamas
Dec 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jacob JosephMartin Hauer-Jensen
Jul 2, 2009·Autonomic & Autacoid Pharmacology·S K WalshC L Wainwright
Aug 12, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mu-qing YangJi-yu Li
Dec 23, 2011·Physiological Research·H MaxováM Vízek

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