PMID: 8589467Oct 1, 1995Paper

Cardiac function of an acute ischemic heart failure model produced by microsphere injection into the left coronary artery. Pressure-volume relationship as determined by a conductance catheter

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
H Kuroda, H Suga

Abstract

The authors produced an acute canine heart failure model by injecting microspheres (phi 15.5 +/- 0.1 mm, 5 x 10(5)) into the left coronary artery, and characterized the model in terms of the pressure-volume relationship obtained by the conductance catheter method. Cardiodynamics of the microsphere injection group (M group: n = 10) and control group (C group: n = 12) were studied with 1) heart rate, 2) aortic pressure, 3) cardiac output (CO), 4) maximal ventricular elastance, 5) effective arterial elastance/maximal ventricular elastance, and 6) external work/pressure-volume area efficiency. With microsphere injection, CO and external work/pressure-volume area efficiency significantly decreased. With administration of dobutamine (5 mg/kg/min), CO and maximal ventricular elastance recovered to normal and aortic pressure became higher than normal. These changes in heart rate, aortic pressure, CO, maximal ventricular elastance, and external work/pressure-volume area efficiency in the M group were comparable in percentage to those in the C groups. Cardiodynamics of this heart failure model generally were stable for 3 hrs after microsphere injection. The authors concluded that this model would be an excellent acute heart failure model...Continue Reading

Citations

Sep 29, 2011·The Journal of Gene Medicine·Michael G KatzCharles R Bridges
Nov 4, 2004·Journal of Molecular and Cellular Cardiology·Yigang WangMuhammad Ashraf
Oct 4, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S KonoM Komeda

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