Cardiac functional evaluation using vector velocity imaging after chemotherapy including anthracyclines in children with cancer.

Korean Circulation Journal
Jong Hun ParkHeung Sik Kim

Abstract

Anthracyclines are effective drugs that are widely used in pediatric cancer treatment. Previous studies have demonstrated that exposure to low-dose anthracyclines (<300 mg/m(2)) induces a progressive decrease in cardiac function during long-term follow-up. The goal of this study was to assess left ventricular function using vector velocity imaging (VVI) in children undergoing low-dose anthracycline therapy. We examined 14 asymptomatic patients who had been treated with anthracyclines and had normal fractional shortening (FS) and ejection fraction (EF). In all of the patients, standard two-dimensional (2D) pulsed and tissue Doppler echocardiographic measurements were taken from an apical 4-chamber view. The peak myocardial velocity, peak strain rate (SR), peak strain, and displacement were obtained from VVI. Data were compared with 14 age-matched healthy controls. From the regional wall motion analysis using VVI in the left ventricle, the peak myocardial velocity and displacement of the lateral wall were increased significantly more than the septum, and there were no significant differences between the patients and the controls. Although systolic strain, and the systolic and diastolic SRs showed no significant differences betwee...Continue Reading

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Citations

Aug 18, 2012·Asia-Pacific Journal of Clinical Oncology·Begül Yağci-KüpeliMünevver Büyükpamukçu
Jan 27, 2015·Ultrasound in Medicine & Biology·Donato MeleRoberto Ferrari
Jan 20, 2015·Pediatric Blood & Cancer·Maëlle de Ville de GoyetStephane Moniotte
Feb 5, 2015·Current Cardiology Reports·Frédéric Poulin, Paaladinesh Thavendiranathan
May 28, 2016·Current Treatment Options in Cardiovascular Medicine·Jyothsna Akam-VenkataSteven E Lipshultz
Oct 2, 2013·Circulation·Steven E LipshultzUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Syngo US Workplace
Statistical Package for Social Science ( SPSS )
Simence
MO

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