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Cardiac glycosides are broad-spectrum senolytics

Nature Metabolism

Dec 5, 2019

Ana GuerreroJesús Gil

Abstract

Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that se...read more

Mentioned in this Paper

Antineoplastic Agents
Neoplastic Cell
Neoplasms
Cellular Stress Response
Senescence Function
Pharmacologic Substance
Apoptosis
Heart
LIMS1 gene
Cell Secretion
141
12
2
16
Paper Details
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Cardiac glycosides are broad-spectrum senolytics

Nature Metabolism

Dec 5, 2019

Ana GuerreroJesús Gil

PMID: 31799499

DOI: 10.1038/s42255-019-0122-z

Abstract

Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that se...read more

Mentioned in this Paper

Antineoplastic Agents
Neoplastic Cell
Neoplasms
Cellular Stress Response
Senescence Function
Pharmacologic Substance
Apoptosis
Heart
LIMS1 gene
Cell Secretion
141
12
2
16
Paper Details
References
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  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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