Cardiac heterometric response: the interplay between Catestatin and nitric oxide deciphered by the frog heart

Nitric Oxide : Biology and Chemistry
R MazzaAlfonsina Gattuso

Abstract

The length-active tension relation or heterometric regulation (Frank-Starling mechanism) is modulated by nitric oxide (NO) which, released in pulsatile fashion from the beating heart, improves myocardial relaxation and diastolic distensibility. The NO signaling is also implicated in the homeometric regulation exerted by extrinsic factors such as autonomic nervous system, endocrine and humoral agents. In the in vitro working frog heart, the Chromogranin A (CGA)-derived peptide, Catestatin (CTS; bovine CGA344-364), exerts a direct cardio-suppressive action through a NOS-NO-cGMP-mediated mechanism which requires the functional integrity of the endocardial endothelium (EE) and its endothelin-1 B type (ETB) receptor. However, functional interplay between NO and CTS and their role in the Frank-Starling response of the frog heart are lacking. Here we show that CTS improves the sensitivity to preload increases similar to that exerted by NO. This effect is abolished by inhibition of NO synthase (L-NAME), guanylate cyclase (ODQ), protein kinase G (KT5823), PI3K (Wortmannin), as well as by the functional damage of EE (Triton X-100) suggesting that CTS operates through an EE-dependent NO release. On the whole, the use of the avascular frog...Continue Reading

References

Nov 16, 1973·Biochemical and Biophysical Research Communications·A WollenbergerE V Bogdanova
May 1, 1994·Circulation Research·A M ShahE G Lakatta
Dec 1, 1996·Journal of Cardiac Failure·L J AndriesS U Sys
Sep 1, 1997·Circulation Research·D J PinskyT Malinski
Jun 21, 2002·Biochemical and Biophysical Research Communications·Lan ZhouKai Y Xu
Jan 9, 2003·Diseases of Aquatic Organisms·Alfonsina GattusoAre Nylund
Jan 28, 2003·Biophysical Journal·Pierre TijskensClara Franzini-Armstrong
Jun 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Alexandra AdlerThomas H Hintze
Jun 2, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Rodolphe FischmeisterGrégoire Vandecasteele
Jun 30, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Paul B MassionJ-L Balligand
Feb 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Maria Pia GalloGiuseppe Alloatti
Mar 10, 2007·Current Medicinal Chemistry·M C Cerra, D Pellegrino
Mar 29, 2007·European Heart Journal·Maurizio PieroniAttilio Maseri
Apr 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sandra CappelloMaria Carmela Cerra
Aug 25, 2007·Cellular and Molecular Life Sciences : CMLS·K B HelleB Tota
May 13, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Rosa MazzaSushil K Mahata
Jun 17, 2008·The Journal of Experimental Biology·Holly A Shiels, Ed White
Jul 1, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Raffaele AciernoBruno Tota
Sep 4, 2009·Proceedings. Biological Sciences·F GarofaloS Imbrogno
Jan 8, 2010·Journal of Molecular and Cellular Cardiology·Pieter P de TombeThomas C Irving
Feb 2, 2010·Regulatory Peptides·Sushil K MahataDaniel T O'Connor
Jul 29, 2010·Clinical and Experimental Hypertension : CHE·Maple M FungDaniel T O'Connor
Aug 17, 2010·General and Comparative Endocrinology·Rosa MazzaAlfonsina Gattuso
May 18, 2011·Nitric Oxide : Biology and Chemistry·Sandra ImbrognoAlfonsina Gattuso

❮ Previous
Next ❯

Citations

Jul 15, 2016·Biomarkers in Medicine·Yilin Zhao, Dan Zhu
Jan 18, 2018·Acta Physiologica·S ImbrognoA Gattuso
Jul 13, 2019·Future Medicinal Chemistry·Teresa PasquaMaria Carmela Cerra

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.